BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Memento EPFL//
BEGIN:VEVENT
SUMMARY:The plasticity of aging 
DTSTART:20110825T100000
DTSTAMP:20260510T064826Z
UID:d38f4fca307b1cb317d1855e80f25c18e9e7840b8aae52f4b24e7810
CATEGORIES:Conferences - Seminars
DESCRIPTION:Dr. Anne BRUNET Assistant Professor of Genetics\, Stanford Uni
 versity School of Medicine\, Stanford\, CA\, USA\nAging\, long thought to 
 be solely the byproduct of “wear and tear”\, is in fact a highly plast
 ic process regulated by a combination of genetic and environmental factors
 . My lab is interested in discovering genes that regulate lifespan and in 
 exploring how the products of these genes integrate environmental stimuli 
 that promote longevity\, such as dietary restriction. The pathway connecti
 ng the insulin signaling pathway to FoxO transcription factors is well kno
 wn to play a pivotal role in aging from worms to mammals. One part of my l
 ab is focused on understanding how the insulin-FoxO pathway acts to regula
 te gene expression programs and cellular responses that are important for 
 longevity in mammals. We are particularly interested in the role of longev
 ity genes and pathways\, including the insulin-FoxO pathway\, in aging neu
 ral stem cells. My lab also uses unbiased approaches in the nematode C. el
 egans and in mammalian cells to identify novel pathways that control organ
 ismal longevity\, particularly in response to dietary restriction. Finally
 \, we are developing the extremely short-lived African killifish N. furzer
 i as a new vertebrate model for aging studies to explore the genetic archi
 tecture of longevity in vertebrates.
LOCATION:AI 1153 https://plan.epfl.ch/?room==AI%201153
STATUS:CONFIRMED
END:VEVENT
END:VCALENDAR