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SUMMARY:Phthiocerol dimycocerosates and phenoglycolipids: key players for 
 mycobacterial pathogenesis 
DTSTART:20110627T150000
DTSTAMP:20260921T174857Z
UID:1c81ad9bcd27cfc3c56606ee26d152c0d6c0e4bc4dc069715c4942f1
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Christophe Guilhot \nRecent advances in the study of myc
 obacterial lipids demonstrate that the classes of lipids known as phthioce
 rol dimycocerosates and phenolglycolipids are major virulence determinant 
 of human pathogens such as Mycobacterium tuberculosis or Mycobacterium lep
 rae. These substances are closely structurally related and their synthesis
  involved a common set of enzymes. However their contribution in pathogene
 sis is different: phthiocerol dimycocerosates (DIM) are clearly required f
 or optimal growth in infected host and have been found in every analyzed i
 solates of M. tuberculosis or M. leprae\; in contrast phenolglycolipids (P
 GL) are dispensable but have been associated with the high virulence of so
 me M. tuberculosis isolates. Recently we uncovered an unexpected structura
 l diversity for these molecules within the M. tuberculosis complex. Howeve
 r the impact of these DIM and PGL structural variation on the interaction 
 with the host remains to be characterized. In this presentation I will dis
 cuss recent findings regarding the molecular mechanisms of action of these
  compounds and new strategies to explore the structure/activities relation
 ship of PGL.
LOCATION:SV 1717a
STATUS:CONFIRMED
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