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SUMMARY:Synaptic dynamics: insight from mathematical modeling...
DTSTART:20130228T110000
DTSTAMP:20260408T085112Z
UID:69517f8f5035d1c82e8e44dcd11fa26a41e3a797214ddaf7947b1146
CATEGORIES:Conferences - Seminars
DESCRIPTION:Dr. David Holcman\, Ecole Normale Superieure\, Ulm\, France\nC
 omplete title of the talk: Synaptic dynamics : insight from mathematical m
 odeling and analysis of superresolution data\nWhat defines synaptic streng
 th at a molecular level and how can we compute the synaptic current?\nTo a
 nswer these questions\, we will present mathematical models that we have d
 eveloped for estimating the current at excitatory synapse based on the pro
 perties of AMPA receptors. We accounted for various geometrical parameters
  of the synapse and also for receptor trafficking.  We will also present 
 statistical methods based on the Langevin's equation to extract local biop
 hysical properties of cell-particle interaction from thousands of individu
 al trajectories.\nWe will focus on AMPA receptor diffusion properties and 
 the strength of their molecular interaction at the sub-diffraction level. 
 Our analysis reveals several attracting potential wells of large sizes\, s
 howing that the high density of AMPARs is generated by physical interactio
 ns with an ensemble of cooperative membrane surface binding sites\, rather
  than molecular crowding. This talk summarizes our long lasting effort to 
 identify key parameters involved in the regulation of synaptic transmissio
 n and plasticity\, processes that underlie learning and memory.
LOCATION:
STATUS:CONFIRMED
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