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SUMMARY:Transition Metal-Catalyzed Fluorination of Organic Compounds
DTSTART:20130508T171500
DTEND:20130508T183000
DTSTAMP:20260916T084334Z
UID:3d88d96cd63865987a8e8b962b8d2c482340dcb6cf11fbced51eb4eb
CATEGORIES:Conferences - Seminars
DESCRIPTION:Professor Liu Guosheng\, State Key Laboratory of Organometalli
 c Chemistry\, Shanghai Institute of Organic Chemistry\,  Shanghai\nTransi
 tion Metal-Catalyzed Fluorination\nGuosheng Liu\nState Key Laboratory of O
 rganometallic Chemsitry\, Shanghai Institute of Organic Chemistry\, Chines
 e Academy of Sciences\nE-mail: gliu@mail.sioc.ac.cn\nAbstract:\nIntroducin
 g fluorine into organic molecules significantly improves properties such a
 s solubility\, bioavailability and metabolic stability\, which are of grea
 t importance in pharmaceuticals. Despite the utilities of organofluorine c
 ompounds\, relatively few methods exist for selective carbon–fluorine bo
 nd formation\, especially when compared to methods for other carbon–halo
 gen bond formations. In recent years\, transition metal-catalyzed fluorina
 tion of organic compounds has received much attention.\nIn this talk\, I
 ’d like to introduce our efforts in the development palladium- catalyzed
  fluorination of alkenes\, in which two strategies were applied to constru
 ct C-F bonds\, such as oxidative fluorination of C-Pd bonds\, and fluoropa
 lladation of olefins. In addition\, more catalytic fluorinations by other 
 metals\, such as Ag and Cu\, will be discussed as well. Specifically\, tho
 se catalytic systems could be used to synthesize varieties of fluorinated 
 heterocycles\, which might be used as potential skeleton for the new drugs
 .\nScheme 1: Transition metal-Catalyzed Fluorination
LOCATION:UNIL\, Génopode\, auditorium B https://planete.unil.ch/plan/?loc
 al=GEN-2006
STATUS:CONFIRMED
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