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SUMMARY:Defying the Stereotype: Cyclic AMP and Mycobacteria
DTSTART:20110621T140000
DTSTAMP:20260406T030009Z
UID:83eb0dc98cfec9a3bf25c771255d66c27f8b7c2bd873ca8ec08d6cd4
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Sandhya S. Visweswariah\, Indian Institute of Science (D
 epartment of Molecular Reproduction\, Development and Genetics)\nCyclic AM
 P is used as a second messenger in almost all forms of life. This talk wil
 l highlight unique features of cyclic AMP-mediated signalling in mycobacte
 ria\, that defy the existing paradigms. The biochemical and structural cha
 racterization of a number of mycobacterial adenylyl cyclases has demonstra
 ted that their activities are controlled by mechanisms distinct from that 
 seen in eukaryotes and other prokaryotes. The product of the rv0805 gene\,
  with orthologs present only in slow growing mycobacteria\, is capable of 
 hydrolyzing cAMP. However\, the same enzyme also appears to alter the prop
 erties of the cell wall in a cAMP-independent manner\, suggesting a moonli
 ghting function for Rv0805. Cyclic AMP has a number of novel downstream ta
 rgets in mycobacteria\, one of them being a cAMP-dependent protein lysine 
 acetyl transferase. It is therefore clear that the synthesis\, degradation
  and utilization of cAMP in mycobacteria occur by mechanisms that are dist
 inct from that seen in other bacteria or in eukaryotes. Therefore\, target
 ing cAMP-mediated signalling processes may aid in our efforts to understan
 d the mechanisms utilized by mycobacteria to cause disease.
LOCATION:AI 1153 https://plan.epfl.ch/?room==AI%201153
STATUS:CONFIRMED
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