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SUMMARY:Advances in Intelligent Hydrogels for Recognitive and Protein Deli
 very Systems
DTSTART:20130704T114500
DTEND:20130704T124500
DTSTAMP:20260407T141526Z
UID:86d8d0c1711c8cac562acec214ca77ed434ef2ba9fe8966dcc4ed937
CATEGORIES:Conferences - Seminars
DESCRIPTION:Nicholas A. Peppas\, Sc.D.\, The University of Texas\, Austin\
 , TX (USA)\nBio:   Our research contributions have been in several areas 
 of drug delivery\, biomaterials\, biomolecular engineering\, mass transfer
 \, kinetics and reaction engineering\, polymers and biomedical engineering
 . The multidisciplinary approach of thiis research in biomolecular enginee
 ring blends modern molecular and cellular biology with engineering to gene
 rate next-generation systems and devices\, including bioMEMS with enhanced
  applicability\, reliability\, functionality\, and longevity. The fundamen
 tal studies of his group have provided valuable results on biomaterials de
 sign and development.Our group is known for our work on the preparation\, 
 characterization and evaluation of the behavior of compatible\, cross link
 ed polymers known as hydrogels\, which have been used as biocompatible mat
 erials and in controlled release devices\, especially in controlled delive
 ry of drugs\, peptides and proteins\, development of novel biomaterials\, 
 biomedical transport phenomena\, and biointerfacial problems. Our polymer 
 research has examined fundamental aspects of the thermodynamics of polymer
  networks in contact with penetrants\, the conformational changes of netwo
 rks under load or in the presence of a diluent\, the anomalous transport o
 f penetrants in glassy polymers\, and the kinetics of fast UV-polymerizati
 on reactions. In the field of controlled release\, his group has provided 
 the fundamental basis for a rational development of such systems. In addit
 ion\, this work has led to a series of novel controlled release systems kn
 own as swelling controlled release systems\, a series of pH-sensitive devi
 ces for drug delivery and a wide range of bio- and mucoadhesive systems. O
 ther biomedical work of his group had dealt with understanding of transpor
 t of biological compounds in tissues\, analysis of polymer/tissue interact
 ions\, and understanding of the behavior of biomembranes.\nDISTINGUISHED L
 ECTURE IN BIOLOGICAL ENGINEERING\nEngineering the molecular design of inte
 lligent hydrogels by controlling recognition and specificity is the first 
 step in coordinating and duplicating complex biological and physiological 
 processes. We address design and synthesis characteristics of novel cross-
 linked networks capable of protein release as well as artificial molecular
  structures capable of specific molecular recognition of biological molecu
 les. Recent developments in protein delivery have been directed towards th
 e preparation of targeted formulations for protein delivery to specific si
 tes\, use of environmentally-responsive polymers to achieve pH- or tempera
 ture-triggered delivery\, usually in modulated mode\, and improvement of t
 he behavior of their mucoadhesive behavior and cell recognition. Molecular
  imprinting and micro imprinting techniques\, which create stereo-specific
  three-dimensional binding cavities based on a biological compound of inte
 rest\, can lead to preparation of biomimetic materials for intelligent dru
 g delivery\, drug targeting\, and tissue engineering. We have been success
 ful in synthesizing novel glucose- and protein-binding polymers based on n
 on-covalent directed interactions formed via molecular imprinting techniqu
 es within aqueous media.
LOCATION:SV 1717A http://map.epfl.ch/?room=sv1717a
STATUS:CONFIRMED
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