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SUMMARY:AMP-activated Protein Kinase: A next generation target for total m
 etabolic control
DTSTART:20110622T110000
DTSTAMP:20260601T231024Z
UID:3137b7f2f445743aaa50dedebf49e5f1be8f2b337a16dd840efaca21
CATEGORIES:Conferences - Seminars
DESCRIPTION:Dr. Javed IQBAL -Institute of Life Sciences\, University of Hy
 derabad\, India\nAMPK is an enzyme that works as a fuel gauge\, being acti
 vated in conditions of high phosphate depletion. In the liver\, activation
  of AMPK results in decreased production of plasma glucose\, cholesterol\,
  triglyceride and enhanced fatty acid oxidation. AMPK is also robustly act
 ivated by skeletal muscle contraction and myocardial ischemia\, and is inv
 olved in the stimulation of glucose transport and fatty acid oxidation by 
 these stimuli. In adipose tissue\, activated AMPK inhibits deposition of f
 at\, but enhances breakdown and burning of stored fat\, resulting in reduc
 tion of body weight. This talk will describe our initial finding demonstra
 ting that AMPK can phosphorylate perilipin to attenuate this protective ef
 fect and plays an important role in lipolysis indicating that perilipin is
  a substrate of AMPK and modulation of AMPK-ACC-Perilipin activities may b
 e a potential useful therapy for metabolic syndrome and obesity. 
LOCATION:AI 1153 https://plan.epfl.ch/?room==AI%201153
STATUS:CONFIRMED
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