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BEGIN:VEVENT
SUMMARY:IC Colloquium : Graphical approaches to Biological Problems
DTSTART:20131021T161500
DTEND:20131021T173000
DTSTAMP:20260510T042919Z
UID:d8a8438364e96469699c6fc5bb3b9ad2d16034812ac7b074b3f2e38d
CATEGORIES:Conferences - Seminars
DESCRIPTION:Ernest Fraenkel - Massachusetts Institute of Technology\nAbstr
 act\nBiology has been transformed by new technologies that provide detaile
 d descriptions of the molecular changes that occur in diseases. However\, 
 it is difficult to use these data to reveal new therapeutic insights for s
 everal reasons. Despite their power\, each of these methods still only cap
 tures a small fraction of the cellular response. Moreover\, when different
  assays are applied to the same problem\, they provide apparently conflict
 ing answers.  I will show that network modeling reveals the underlying co
 nsistency of the data by identifying small\, functionally coherent pathway
 s linking the disparate observations. We have used these methods to analyz
 e how oncogenic mutations alter signaling and transcription and to priorit
 ize experiments aimed at discovering therapeutic targets.Biography\nErnest
  Fraenkel was first introduced to computational biology in high school whe
 n the field did not yet have a name.  His early experiences with Professo
 r Cyrus Levinthal of Columbia University taught him that biological insigh
 ts often come from unexpected disciplines. After graduating summa cum laud
 e from Harvard College in Chemistry and Physics he obtained his Ph.D. at M
 IT in the department of Biology and did post-doctoral work at Harvard. As 
 the field of Systems Biology began to emerge\, he established a research g
 roup in this area at the Whitehead Institute and then moved to the Departm
 ent of Biological Engineering at the Massachusetts Institute of Technology
 . His research group takes a multi-disciplinary approach involving tightly
  connected computational and experimental methods to uncover the molecular
  pathways that are altered in cancer\, neurodegenerative diseases\, and di
 abetes.
LOCATION:BC 420 https://plan.epfl.ch/?room==BC%20420
STATUS:CONFIRMED
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