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SUMMARY:New Insights into Lymphatic Vessel Immune and Drainage Function
DTSTART:20130624T121500
DTSTAMP:20260427T201534Z
UID:c2484e2eb48bbad6676ac2eb650e25e6e69ef6be219a8dade6e76f16
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Cornelia Halin Winter\, ETHZ\nBio: Cornelia Halin Winter
 \, born on 4th of October 1974 in Zurich\, Switzerland\, studied biochemis
 try at ETH Zurich (1993 – 1998). After obtaining her diploma\, she spent
  6 months working as an intern in the Department of Molecular Oncology at 
 Genentech Inc.\, San Francisco\, USA. From 1999 – 2002 she performed her
  PhD thesis in the laboratory of Prof. Dr. Dario Neri at the Institute of 
 Pharmaceutical Sciences of ETH Zurich\, working on immunocytokines and tar
 geted tumor therapy. Her dissertation was awarded the ETH Zurich Silver Me
 dal. From 2002 -2005\, Cornelia Halin Winter performed a post-doc in the l
 aboratory of Prof. Dr. Ulrich von Andrian at Harvard Medical School\, Bost
 on\, USA\, working in the field of leukocyte trafficking. In 2005 she retu
 rned to the Institute of Pharmaceutical Sciences of ETH Zurich to work as 
 a post-doc and group leader in the laboratory of Prof. Dr. Michael Detmar 
 in the field of lymphatic vessel biology. In June 2008 she received an app
 ointment as Assistant Professor at ETH Zurich. Her research focuses on leu
 kocyte migration and vascular biology in the context of inflammation and t
 umor growth. Since September 2011 Cornelia Halin Winter is a consultant fo
 r Philochem AG (Zurich\, Switzerland) in the field of immunocytokines.\nLy
 mphatic Vessels (LVs) are important for fluid drainage and also fulfill es
 sential immune functions by transporting leukocytes and lymph-borne antige
 n to draining lymph nodes (dLNs). Particularly dendritic cell (DC) migrati
 on via afferent lymphatic vessels to draining lymph nodes (dLNs) is an imp
 ortant step in the induction of adaptive immunity\, but the interactions b
 etween DCs and lymphatic vessels are only now starting to be unraveled at 
 the cellular level. Our group has recently established a new intravital mi
 croscopy (IVM) model to image DC migration in the ear skin of transgenic m
 ice with red fluorescent LVs. These experiments have revealed that DCs act
 ively migrate within initial lymphatic capillaries and appear to only be p
 ropagated by lymph once they reach larger collecting vessels. In the first
  part of my presentation I will introduce our IVM model and report on the 
 identification of first molecules that determine the velocity and directio
 nality of intralymphatic DC migration. In the second part of my presentati
 on\, I will talk about the role of interleukin-7 (IL-7) in lymphatic vesse
 l biology. IL-7 is an immune-stimulatory cytokine\, which currently is in 
 clinical development for the treatment of cancer and viral infections. We 
 have recently observed that lymphatic endothelial cells (LECs) in the skin
  and in LNs not only produce IL-7 but also express the IL-7 receptor chain
 s. Experiments in different mouse models have revealed an unexpected new r
 ole of IL-7 in supporting lymphangiogenesis and lymphatic drainage\, indic
 ating that IL-7 contributes to immune function by supporting the lymphatic
  vascular system.
LOCATION:SV 1717A http://plan.epfl.ch/?reset_session&room=sv1717a
STATUS:CONFIRMED
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