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SUMMARY:Lymphatic Vessels and Fat
DTSTART:20130923T110000
DTSTAMP:20260407T043500Z
UID:edc4010ffce89866f55601762bb919af8cf9d5becc94164b7f549a05
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Gwendalyn J. Randolph\, Washington University\, St. Loui
 s\, MO (USA)\nBio: My laboratory’s research integrates the study of mono
 cytes\, monocyte-derived cells\, and dendritic cells with vascular and lym
 phatic vessel biology. We have pioneered assays to study migration of thes
 e immune cells to lymph nodes in various tissues. We have also developed a
 ssays to study the differentiation and migration of human monocytes and de
 ndritic cells across vascular and lymphatic barriers.\nCurrent studies exa
 mine the recruitment of monocytes to sites of acute and chronic inflammati
 on (e.g.\,\natherosclerotic plaques) and then follow the fate of these cel
 ls thereafter. Through our studies on the migration of monocyte-derived de
 ndritic cells and other dendritic cells through lymphatic vessels\, we hav
 e also taken a keen interest in the functional properties of lymphatic ves
 sels and the adipose tissue that surrounds them. We are thus branching out
  to explore crosstalk between immune cells and lymphatics and how these in
 teractions might affect lymphatic function\, immune and inflammatory respo
 nses\, and adipose tissue.\nDISTINGUISHED LECTURE IN BIOLOGICAL ENGINEERIN
 G\nLymphatic vessels have a well-established role in fat transport\, parti
 cularly from the intestine\, as all long chain fatty acids and cholesterol
  are absorbed only via the lymphatic vasculature. Recently\, my laboratory
  expounded upon this paradigm to ask whether lymphatic vessels were also c
 ritical to export of fats from other tissues. We found that cholesterol re
 moval from many tissues\, including atherosclerotic plaques\, was dependen
 tupon the lymphatic vasculature. This finding has important implications f
 orstrategies related to the progression and treatment of atherosclerosis.
   Lymphatic vessels draining the aorta run through aortic adipose tissue.
  We have taken a special interest in the biological scenarios in which fat
  depots and lymphatic vessels co-localize and affect each other. This semi
 nar will discuss frontiers in lymphatic vessel and adipose tissue crosstal
 k\, including the role of lymphatic vessels and peri-aortic fat in cardiov
 ascular disease\, the possible role of lymphatic vessel – adipose tissue
  crosstalk in immune responses carried out in lymph nodes\, and the connec
 tions between “creeping fat” and the lymphatic vasculature in inflamma
 tory bowel disease. Data from mouse and human studies will be presented. T
 he work discussed is expected to appeal to those interested in vascular an
 d lymphatic biology\, immunology\, and metabolism.
LOCATION:SV 1717A http://plan.epfl.ch/?reset_session&room=sv1717a
STATUS:CONFIRMED
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