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SUMMARY:Auditory processing in comatose patients during and after therapeu
 tic hypothermia
DTSTART:20130604T140000
DTEND:20130604T150000
DTSTAMP:20260503T192235Z
UID:a008bc2bc663b73071ac71a749083b30719aa91ef343e70bd3227c70
CATEGORIES:Conferences - Seminars
DESCRIPTION:Marzia De Lucia\, Lemanic Center for Biomedical Imaging\, CHU
 V\nAuditory evoked potentials (AEPs) have been extensively investigated in
  comatose patients as one of the markers of intact neural functions. Typic
 ally\, significant differential AEPs in response to different varieties of
  sounds has been considered as a good predictor of chance of surviving. Ho
 wever most of previous studies have been conducted at late stages of coma\
 , i.e. weeks or months\, and before the introduction of therapeutic hypoth
 ermia\, a treatment which has significantly increased the chance of surviv
 ing.\nI will present the results of three AEPs studies conducted in post-a
 noxic comatose patients during and after therapeutic hypothermia (i.e. dur
 ing first two days of coma)\, providing evidence of three main phenomena. 
 First\, comatose patients during acute coma can discriminate frequent vers
 us rare auditory stimuli in oddball paradigms as well as categories of env
 ironmental sounds despite their level of auditory discrimination is not pr
 edictive of their final outcome. Second\, the progression from hypothermia
  to normothermia of auditory discrimination between frequent and rare type
 s of stimuli is informative of patients’ chance of awakening. Third\, co
 matose patients can exhibit more accurate auditory discrimination than age
 -matched controls suggesting a critical role of therapeutic hypothermia an
 d sedation in reducing physiological background activity unrelated to stim
 ulus processing.
LOCATION:SV1717a http://plan.epfl.ch/?room=SV%201717A
STATUS:CONFIRMED
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