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SUMMARY:How ionic conductances help to shape temporal firing characteristi
 cs
DTSTART:20110506T121500
DTSTAMP:20260407T081411Z
UID:5b34761fc2189144e2720e05f27850334db6f0c1cb32f04f3c44807c
CATEGORIES:Conferences - Seminars
DESCRIPTION:Susanne\, SCHREIBER\, Institute for Theoretical Biology\, Humb
 oldt University Berlin\nAlthough for bare spike generation only very few i
 onic conductances would be needed\, neurons can express a large variety of
  ion channels with diverse properties. It is straightforward to assume tha
 t the conductances play an important role in shaping neural responses. Her
 e\, we present mechanisms by which ionic conductances can influence two te
 mporal characteristics of the spike code: spike-timing reliability and spe
 cific firing patterns. In the first case\, a cellʼs ion channel compositi
 on determines how spike-timing precision depends on the input frequency. I
 n addition\, ionic conductances can also modify the extent to which noise 
 affects spike-timing precision. In the second case\, a resonance in the su
 bthreshold membrane potential - which is known to result from specific ion
 ic conductances with slow dynamics - leads to clustered firing patterns. T
 o fully account for the observed clustered patterns in stellate cells of t
 he entorhinal cortex\, however\, also spike-induced currents have to be co
 nsidered. 
LOCATION:BC 01 https://plan.epfl.ch/?room==BC%2001
STATUS:CONFIRMED
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