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SUMMARY:Cytomegalovirus: the Rule Breaker of Virology
DTSTART:20130527T141500
DTEND:20130527T151500
DTSTAMP:20260916T203808Z
UID:b77b548bea03f46b1fdcc9c36b2fd0cb576f0423021a2be7e9835126
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Timothy F. Kowalik\, University of Massachusetts Medical
  School\, Worcester MA (USA)\nBio: Timothy Kowalik received his B.S. degre
 e in Biology and Mathematics from Belmont Abbey College in 1982. He receiv
 ed his M.S. (1986) and his Ph.D. (1989) in Molecular Biology and Virology 
 from Utah State University. Dr. Kowalik did postdoctoral research on virus
 -cell interactions from 1990-1993 at the Lineberger Cancer Center of the U
 niversity of North Carolina. From 1993-1996\, he continued his postdoctora
 l studies in the Department of Genetics at Duke University Medical Center 
 where he analyzed the relationship between the cell cycle and apoptosis. D
 uring his postdoctoral training\, Dr. Kowalik was a Fellow of the Damon Ru
 nyon-Walter Winchell Cancer Research Fund and a Leukemia Society of Americ
 a Special Fellow. In 1996\, Dr. Kowalik joined the Department of Molecular
  Genetics and Microbiology at the University of Massachusetts Medical Scho
 ol where he is an associate professor.\nThe field of virology is a world o
 f paradigms. For example\, viruses with DNA genomes inactivate tumor suppr
 essors to prevent antiviral effects. Also\, viruses with RNA genomes are g
 enetically highly variable\, whereas genetic information carried by DNA vi
 ruses is stable by virtue of proofreading activity associated with DNA rep
 licases. Cytomegaloviruses (CMV) are common herpesviruses that coevolved w
 ith vertebrates. Human CMV is perhaps the most ancient virus that infects 
 Homo sapiens. Recent studies have suggested that HCMV does not follow para
 digms very well. Data will be presented that shows HCMV inducing a robust 
 DNA damage response in infected cells\, which activates the “antiviral
 ” p53 tumor suppressor\, yet HCMV requires this DNA damage response to r
 eplicate. Likewise\, evidence of genomic diversity and rapid evolution of 
 HCMV populations has been uncovered. The significance of these findings to
  HCMV infections and fundamental notions of genomic stability of DNA genom
 es will be discussed in the context of paradigms in virology.
LOCATION:AI 1 153 http://plan.epfl.ch/?reset_session&room=ai1153
STATUS:CONFIRMED
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