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SUMMARY:LCN Seminar: Natural firing patterns reduce sensitivity of synapti
 c plasticity to spike-timing
DTSTART:20130530T151500
DTSTAMP:20260506T084537Z
UID:3b8ffe42f709256cfb50d3724c5c9c272bbbb1a288d13e9385c4099d
CATEGORIES:Conferences - Seminars
DESCRIPTION:Michael GRAUPNER\; Center for Neural Science\, NY University\n
 Synaptic plasticity is sensitive to both the rate and the timing of pre- a
 nd postsynaptic spikes. In experimental protocols used to induce plasticit
 y\, the imposed spike trains are regular and the relative timing between e
 very pre- and postsynaptic spike is fixed. This is at odds with natural fi
 ring patterns observed in the cortex of intact animals\, where cells fire 
 irregularly and the timing between pre- and post-synaptic spikes varies. T
 o investigate synaptic changes elicited by in vivo-like irregularly firing
  at different rates and realistic correlations between pre- and post-synap
 tic spikes\, we use numerical simulations and mathematical analysis of syn
 aptic plasticity models. We concentrate on classical spike-timing based mo
 dels and a calcium-based model. We show that standard stimulation protocol
 s overestimate the influence of spike-timing on synaptic plasticity. Using
  a simple modification of regular spike-pair protocols\, we allow for neur
 ons to fire irregularly. Such irregular spike-pairs reduce the amplitude o
 f potentiation and depression obtained by varying the time difference betw
 een pre- and postsynaptic spikes. This protocol allows us to quantify the 
 relative effects of firing rate and timing in natural firing patterns\, an
 d to predict changes induced by an arbitrary correlation function between 
 pre- and post-synaptic spikes. We show that spike correlations change syna
 ptic plasticity at low firing rates in all models\; whereas their influenc
 e becomes negligible at high firing rates for the calcium-based model but 
 remains significant for the spike timing-based models. Our findings yield 
 predictions for novel experiments and help bridge the gap between existing
  results on synaptic plasticity and plasticity occurring under natural con
 ditions
LOCATION:BC 02 https://plan.epfl.ch/?room==BC%2002
STATUS:CONFIRMED
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