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SUMMARY:Molecular Modeling of Membrane Embedded Proteins
DTSTART:20130531T180000
DTEND:20130531T190000
DTSTAMP:20260928T065608Z
UID:6ece915ce78b548e2cb181489953c35e8f5320cc95d472c8a65332fe
CATEGORIES:Thesis defenses
DESCRIPTION:Thomas Lemmin\, Dal Peraro Lab (LBM)\nAt present\, the experim
 ental determination of high-resolution membrane protein structures is diff
 icult. Combined with in vitro data\, molecular modeling is therefore a val
 uable tool for the structural determination at near-atomistic resolution o
 f this class of proteins. This thesis work shows how molecular simulations
  and their interplay with available experimental input can help advance th
 e understanding of the mechanism of complex biological systems and process
 es on a molecular scale. These results\, in particular\, go well beyond th
 e current understanding of the functioning of two transmembrane proteins r
 elevant for human health: the PhoQ histidine kinase and the Amyloid Precur
 sor Protein. Furthermore\, the computational approaches and procedures dev
 eloped in these projects will hopefully promote novel integrated strategie
 s for investigating biological systems.
LOCATION:SV1717a http://map.epfl.ch/?room=sv1717a
STATUS:CONFIRMED
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