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SUMMARY:Deciphering the hematopoietic niche: a model study in Drosophila
DTSTART:20130614T110000
DTEND:20130614T120000
DTSTAMP:20260407T163738Z
UID:18a3ce8cda02f8d8f05fd3ae1e107b3440ece082537a7f42f77c7e47
CATEGORIES:Conferences - Seminars
DESCRIPTION:Michèle CROZATIER\nVertebrate Hematopoietic Stem Cells (HSCs)
  are responsible for lifelong maintenance of blood cells. Deregulation of 
 hematopoiesis is at the origin of numerous pathologies including leukemia.
  Maintaining HSCs depends on signals provided by their micro-environment c
 alled the « niche ». The cellular and molecular communications between H
 SCs and their niche is very complex. The discovery of a niche\, called the
  Posterior Signaling Center (PSC)\, responsible for maintaining a pool of 
 hematopoietic progenitors in the Drosophila hematopoietic organ\, the lymp
 h gland (LG)\, has made Drosophila a model to investigate the formation an
 d function of a hematopoietic niche in vivo. In addition to the PSC\, the 
 LG consists of a medullary zone (MZ) and a cortical zone (CZ)\, which cont
 ain progenitors and differentiated hemocytes (blood cells)\, respectively.
  A specific type of hemocyte\, called lamellocyte\, is devoted to encapsul
 ation of foreign bodies too large to be phagocytised\, and differentiates 
 only under specific conditions such as wasp parasitism. Under physiologica
 l conditions\, the number of niche cells is tightly controlled by Dpp/BMP 
 and Robo/Slit signaling pathways to maintain blood cell homeostasis. New i
 nsights into the regulatory networks that link niche size and hemocyte hom
 eostasis and parallels between Drosophila and mammalian hematopoiesis will
  be discussed.
LOCATION:AI 1153 https://plan.epfl.ch/?room==AI%201153
STATUS:CONFIRMED
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