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BEGIN:VEVENT
SUMMARY:BMI Seminar // “The match/mismatch hypothesis of stress-related 
 disorders: Modulation by ge
DTSTART:20131030T121500
DTEND:20131030T131500
DTSTAMP:20260428T110812Z
UID:fcb8c23ff3e859a17516e719f85a9a4199543493425a61b90247956b
CATEGORIES:Conferences - Seminars
DESCRIPTION:Mathias V. Schmidt\nMax-Planck Institute of Psychiatry\, Munic
 h\, Germany\nAbstract :\nChronic stress is widely regarded as key risk fac
 tor for a variety of diseases\, including depression. Yet\, while some ind
 ividuals are vulnerable to stress\, others are remarkably resilient. It se
 ems clear that genetic predispositions interact with environmental demands
  such as chronic stress and modulate its long-term outcome. In addition\, 
 there is abundant evidence that environmental circumstances early in life 
 are capable of shaping the adult phenotype. In the last years two seemingl
 y opposing views on early life stress have emerged\, the two-hit model and
  the mismatch model. While the first hypothesis states that aversive exper
 iences early in life predispose individuals to be more vulnerable to avers
 ive challenges later in life\, the second hypothesis argues that aversive 
 experiences early in life result in individuals that are better adapted to
  aversive challenges later in life. There are published data that support 
 either hypotheses\, but the interaction with genetic predispositions has r
 arely been addressed. In my presentation I will propose that both views ma
 y be accurate and that the outcome of an early-life stress exposure depend
  on the genetic background of the individual. In addition\, even within th
 e same individual certain phenotypes may be progressively affected by mult
 iple stress exposures (two-hit model)\, while other phenotypes would be mo
 st affected under mismatched conditions. I will illustrate the potential o
 f genetic variations to modulate the outcome of early life adversity and d
 iscuss research strategies necessary to address the issue of genetic*devel
 opment*environment interaction.
LOCATION:SV1717A
STATUS:CONFIRMED
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