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SUMMARY:Regulation of proteasome activity – the role of insulin/IGF-1 si
 gnaling 
DTSTART:20130710T103000
DTEND:20130710T113000
DTSTAMP:20260916T044002Z
UID:387124a1106d29e6a8e9a0f08c1d3f566935c6e696920fafbf33eac5
CATEGORIES:Conferences - Seminars
DESCRIPTION:Olli MATILAINEN\, M.Sc.\nResearch Programs Unit\, Translationa
 l Cancer Biology Research Program\, Biomedicum Helsinki\nUniversity of Hel
 sinki\, Finland\nLIMNA seminar - Lausanne Integrative Metabolism and Nutri
 tion Alliance\nThe proteasome is responsible for the major part of control
 led protein degradation in the cell\, and impairments in its function have
  been associated with many severe\, usually age-related disorders. By usin
 g C. elegans as model organism\, we found that aging-related insulin/IGF-1
  signaling (IIS) regulates proteasome activity through SKN-1 and DAF-16 tr
 anscription factors. Moreover\, we discovered that DAF-16 regulates the ex
 pression of proteasome-associated deubiquitinating enzyme ubh-4\, which we
  show functioning as a tissue-specific proteasome regulator. Altogether\, 
 our results establish a mechanism linking IIS to proteasome activity and a
 dd one more branch to IIS mediated maintenance of cellular protein homeost
 asis.
LOCATION:SV1717A http://map.epfl.ch/?room=sv1717a
STATUS:CONFIRMED
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