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SUMMARY:Writing and Reading DNA Methylation
DTSTART:20130701T121500
DTEND:20130701T131500
DTSTAMP:20260408T025925Z
UID:666f1deb2b779ebaedfc1ace7aadacba551f6fb48e506181632130ba
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Dirk Schübeler\, Friedrich Miescher Institute for Biome
 dical Research\, Basel (CH)\nBio: 1998  PhD\, Technical University\, Brau
 nschweig\, Germany\n1995  MSc\, Technical University\, Braunschweig\, Ger
 many\nPositions held\n2008-  Senior Group Leader\, Friedrich Miescher Ins
 titute for Biomedical Research\, Basel\n2003-2007  Junior Group Leader\, 
 Friedrich Miescher Institute for Biomedical Research\, Basel\n1998-2003  
 Postdoctoral Fellow\, Fred Hutchinson Cancer Research Center\, Seattle\nHo
 nours\n2012  Election to Academia Europaea\n2011  Adjunct Professor\, Un
 iversity of Basel\n2009  Member\, EMBO\n2009  Privatdozent\, University 
 of Basel\n2008  European Research Council Starting Independent Researcher
  Award\n2007  Friedrich Miescher Prize\, Swiss Society for Biochemistry\n
 2006  EMBO Young Investigator Award\n2006  Member\, Epigenome Network of
  Excellence\n2000-2002  Postdoctoral Fellowship\, Rett Syndrome Research 
 Foundation\n1998-2000  Postdoctoral Fellowship\, Deutsche Forschungsgemei
 nschaft\n1997  Thesis award\, GBF Förderpreis\n1995-1998  Graduate Fell
 owship\, Foundation of the German Chemical Industry\nAbstract:\nChromatin 
 and DNA modifications have emerged as a critical component for gene regula
 tion in higher eukaryotes. Yet how these epigenetic variables are targeted
  to specific sites of the genome and how they influence cellular potential
  and identity is still poorly understood.\nWe have generated global maps o
 f DNA methylation\, histone modifications and replication in higher eukary
 otes using stem cell differentiation as a dynamic cellular model for pluri
 potency\, lineage commitment and terminal differentiation.\nThis analysis 
 allowed us to identify genomic sites that change their epigenetic status c
 ell-state specific. Based on the resulting datasets we generate models how
  these epigenetic variables are targeted\, which we test by genetic pertur
 bation of involved modifiers and mutation of putative recruiting elements.
  In order to systematically define how chromatin components are targeted t
 o the genome we have combined epitope tagging with genome editing enabling
  us to study the genomic location of a family of proteins that are putativ
 e readers of DNA methylation.\nOur results suggest that the actual DNA seq
 uence of regulatory regions is a key determinant of their DNA methylation 
 and chromatin state\, a finding\, which will be discussed in the light of 
 current models of the function of epigenetic restriction during developmen
 t.Relevant recent publications:\n- Tuncay Baubec\, Robert Ivanek\, Florian
  Lienert and Dirk Schübeler. (2013) Methylation-dependent and -independen
 t genomic targeting principles of the MBD protein family\, Cell\, 153\, 48
 0–492\n- Michael B. Stadler\, Rabih Murr\, Lukas Burger\, Robert Ivanek\
 , Florian Lienert\, Anne Schöler\, Christiane Wirbelauer\, Edward J. Oake
 ley\, Dimos Gaidatzis\, Vijay K. Tiwari and Dirk Schübeler. (2011) DNA bi
 nding factors shape the mouse methylome at distal regulatory regions\, Nat
 ure\, 480\, 490-495\n- Florian Lienert\, Christiane Wirbelauer\, Indrani S
 om\, Ann Dean\, Fabio Mohn and Dirk Schübeler. (2011) Identification of g
 enetic elements that autonomously determine DNA methylation states\, Natur
 e Genetics\, 43\, 1091-97
LOCATION:SV1717a http://map.epfl.ch/?room=sv1717a
STATUS:CONFIRMED
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