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SUMMARY:Neonatal overfeeding permanently programs late onset obesity and d
 iabetic phenotype
DTSTART:20130821T103000
DTEND:20130821T113000
DTSTAMP:20260505T063608Z
UID:a66018b5985d969d82289dd4a1305c47a854d854d20028413db4cf54
CATEGORIES:Conferences - Seminars
DESCRIPTION:Thais PENTINAT\, PhD student\nEndocrine division\, Hospital Sa
 nt Joan de Déu\, Barcelona\, Spain\nEpidemiological and clinical studies 
 show that rapid weight gain in early life is strongly associated with seve
 ral components of the metabolic syndrome several years later. Even more\, 
 accelerated neonatal growth rate may influence diabetes risk in subsequent
  generations.\nIn order to determine which events\, occurring during early
  life\, may determine the adverse metabolic consequences in adulthood\, we
  have developed a mouse model of accelerated growth rate by neonatal overn
 utrition in males (ON). As it happens in humans\, we show that ON mice exh
 ibited accelerated growth and by age 4 months developed many features of t
 he metabolic syndrome\, including obesity\, impaired glucose tolerance and
  insulin resistance. Importantly\, many abnormalities (obesity\, tissue-sp
 ecific insulin resistance) are already detectable by weaning\, before whol
 e body metabolism is altered.\nStrikingly\, early programmed diabetic phen
 otypes are inherited into the following generation offspring\, F2\, throug
 h the paternal lineage. This effect occurred even though mice from F2 have
  not been exposed to nutritional challenges during development. This type 
 of\, environmentally-induced paternal effects strongly implicates the role
  of epigenetic mechanisms in mediating both long-term and transgenerationa
 l effects in ON mice.
LOCATION:AI 1153 https://plan.epfl.ch/?room==AI%201153
STATUS:CONFIRMED
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