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SUMMARY:Sirtuin 2 and insulin resistance: is there a connection?
DTSTART:20130813T103000
DTEND:20130813T113000
DTSTAMP:20260930T202143Z
UID:4d707aac5a1c54c0a34ac3365c38600b9d6bf6f306fc65f6b3ac4d52
CATEGORIES:Conferences - Seminars
DESCRIPTION:Vera LEMOS\, University of Porto\, Portugal\nBio: I am Vera Le
 mos and I graduated in Nutritional Sciences by University of Porto. For th
 e past 2 years\, I have been investigating the role of Sirtuins on metabol
 ism\, trying to emphasize their activation as a therapeutic strategy for t
 he treatment of metabolic diseases. After this\, I was willing to get to k
 now other areas of research to enrich my scientific knowledge and to try t
 o engage in my PhD with a novel multidisciplinary approach\, so I joined G
 ABBA at the University of Porto.\nSince the beginning of this century\, th
 e sirtuin family (SIRT1–SIRT7) of mammalian NAD+-dependent deacetylases 
 and/or ADP ribosyltransferases has received much attention for its regulat
 ory role in a plethora of cellular functions. The dependence of sirtuins o
 n NAD+ links their enzymatic activity to cellular metabolic status. Indeed
 \, emerging evidence suggests a role for sirtuins in the regulation of var
 ious metabolic pathways in response to nutrient availability. Our results 
 showed that SIRT2 expression is downregulated in insulin-resistant cells a
 nd tissues\, and this is paralleled by increased oxidative stress levels a
 nd mitochondrial dysfunction. By using in vitro cell based studies complem
 ented with whole animal and human studies\, we aimed at strengthening SIRT
 2’s position as a future target for the prevention and/or treatment of t
 he current epidemic of metabolic disorders\, such as insulin resistance.
LOCATION:AI 1153 https://plan.epfl.ch/?room==AI%201153
STATUS:CONFIRMED
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