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SUMMARY:Spike timing and firing rate dependent plasticity as calcium-induc
 ed transitions in a bistable synapse model
DTSTART:20110318T121500
DTSTAMP:20260916T002719Z
UID:bc01dceb262ac8018d73732481636c020d0d381135145474e7434d8b
CATEGORIES:Conferences - Seminars
DESCRIPTION:Nicolas Brunel\, CNRS Paris\nMultiple stimulation protocols ha
 ve been found to be effective in changing synaptic efficacy by inducing lo
 ng-term potentiation or depression in the hippocampus and neocortex. In ma
 ny of those protocols\, increases in post-synaptic calcium concentration h
 ave been shown to play a crucial role. However\, it is still unclear wheth
 er and how the dynamics of the post-synaptic calcium concentration alone d
 etermine the outcome of synaptic plasticity. Here\, we investigate numeric
 ally and analytically a calcium based model of a synapse in which potentat
 ion or depression are described by simple calcium thresholds. We show that
  this model (i) reproduces the diversity of spike-timing dependent plastic
 ity curves observed in different systems\, depending on parameters\; (ii) 
 reproduces quantitatively a large number of specific protocols involving m
 ore complex spike patterns in hippocampal cultures\, and hippocampal and c
 ortical slices.
LOCATION:BC 02 https://plan.epfl.ch/?room==BC%2002
STATUS:CONFIRMED
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