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SUMMARY:Multiplexed coding of the cerebellar Purkinje neurons
DTSTART:20130729T140000
DTEND:20130729T150000
DTSTAMP:20260531T141621Z
UID:a70d26d15974c77154d1cd709122f9ffd7df2044cb47bfce6db64927
CATEGORIES:Conferences - Seminars
DESCRIPTION:Sungho Hong\nMultiplexed coding of the cerebellar Purkinje neu
 rons\nBBP Sectional Seminar Announcement\nMonday\, July 29th\, 2013\,\n14h
 00\, Room "BBP Viz Room"\, QIJ 3rd floor\nSpeaker:\nSungho Hong\nOkinawa I
 nstitute of Science and Technology\,  Japan\nTitle:\nMultiplexed coding o
 f the cerebellar Purkinje neurons\nAbstract:\nA fundamental problem in neu
 roscience is uncovering relationships between neurons and the network in w
 hich they are embedded\, and one of the widely used approaches is to study
  how correlations in their activities arise and impact the network informa
 tion processing. In particular\, correlations between individual neurons a
 nd the overall activity of the network\, often probed by local field poten
 tial (LFP)\, have been useful for investigating how single neurons process
  information in the context of the network.\nI will talk about our recent 
 findings that the correlation of the cerebellar Purkinje neuron (PN) firin
 g to the LFP is dynamic and depends on the behavioral context. We analyzed
  the simultaneous recordings of the cerebellar extracellular potential and
  eye motion from rhesus monkeys during saccadic eye motion task\, and foun
 d that the PN spike-LFP correlation is strong and temporally precise at ce
 rtain transition points in the spiking pattern but otherwise weak. We also
  found that\, while the weak correlation is involved in the slower eye vel
 ocity modulation\, the strongly correlated spikes are related to the rapid
  changes in the eye motion such as saccade onsets.\nRegarding how the PNs 
 transfer information to the downstream\, two opposing views have been deba
 ted: in one\, synchronization in the PN firings is crucial while\, in the 
 other\, the population rate code is used and therefore minimizing the corr
 elations is beneficial. Based on our results\, I will explain that the PN 
 population code can be multiplexed\, i.e.\, the synchronous and asynchrono
 us spikes can coexist and encode different behavioral informations. I will
  also discuss what our findings can imply about how the cerebellar cortex 
 communicates with other brain regions for sensorimotor coordination.\nRele
 vant publications:\n• Ratté\, S.\, Hong\, S.\, De Schutter\, E. and Pre
 scott\, S.A. (2013) Impact of neuronal properties on network coding: Roles
  of spike Initiation dynamics and robust synchrony transfer. Neuron 78\, 7
 58-772.\n• Hong\, S.\, Ratté\, S.\, Prescott\, S.A.\, and De Schutter\,
  E. (2012a). Single neuron firing properties impact correlation-based popu
 lation coding. J. Neurosci. 32\, 1413–28.
LOCATION:BBP Viz Room http://plan.epfl.ch/?zoom=20&recenter_y=5863491.5802
 5&recenter_x=730480.87524&layerNodes=fonds\,batiments\,labels\,information
 \,parkings_publics\,arrets_metro&floor=0&q=qij
STATUS:CONFIRMED
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