BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Memento EPFL//
BEGIN:VEVENT
SUMMARY:Symbiotic Regulatory Loop Between Foxp3+ T Cells\, IgA and Gut Mic
 robiota
DTSTART:20130821T121500
DTEND:20130821T131500
DTSTAMP:20260509T054440Z
UID:de52d50e80aa3ed3184b3566ffe1a43bbccbc10809a9883562271dd9
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Sidonia Fagarasan\, RIKEN\, Yokohama (Japan)\nBio: Sidon
 ia Fagarasan completed training in clinical medicine at Iuliu Hatieganu Un
 iversity of Medicine and Pharmacy in 1990. She did residency and specialit
 y in the Clinical Laboratory for Microbiology\, Biochemistry and Hematolog
 y at the University of Medicine and Pharmacy\, Cluj-Napoca\, and was appoi
 nted to Assistant Professor in 1995. It was during this clinical period in
  Romania that Dr Fagarasan developed a fascination into the mechanisms gov
 erning intestinal immune homeostasis. In 1998\, Dr Fagarasan was invited t
 o Japan as a Mombusho Visiting Researcher and earned PhD from Kyoto Univer
 sity Faculty of Medicine in 2000. In Kyoto she contributed to the discover
 y of Activated Induced Deaminase (AID) with Tasuku Honjo and colleagues. S
 he subsequently demonstrated the critical role of AID in gut homeostasis.S
 ince 2002\, Dr Fagarasan has been team leader of the Laboratory for Mucosa
 l Immunity at the Research Centre for Allergy and Immunology (RCAI)\, RIKE
 N Yokohama\, Japan. Dr. Fagarasan’s research primarily aims to elucidate
  mechanistic regulation and function of the mucosal antibody IgA in the gu
 t.\nA joint GLOBAL HEALTH & BIOENGINEERING Sandwich Seminar\nThe main func
 tion of the immune system is to protect the host against pathogens\, such 
 as bacteria or viruses. However\, unlike the systemic immune system\, the 
 gut immune system does not eliminate microorganisms but instead nourishes 
 rich bacterial communities and establishes advanced symbiotic relationship
 s. Not only that the gut bacteria are essential for nutrient processing\, 
 production of vitamins and protection against pathogens (through competiti
 on for space and nutrients) but the development and maturation of the immu
 ne system depends on these bacteria.\nThe primary individual microbiota (M
 b) probably reflect the maternal hand-over during or immediately after bir
 th. However\, the subsequent shaping of the microbial landscape is likely 
 driven by complex interactions with the host immune system\, through a net
 work of regulatory components involving both the innate and adaptive immun
 e system. Our previous studies demonstrated that the absence of immunoglob
 ulin A (IgA) (the major effector molecule of the adaptive immunity in the 
 gut)\, or the impaired IgA selection in germinal centers (GC) due to dereg
 ulated T cell control\, severely affects the balance of gut bacterial comm
 unities\, resulting in massive activation of the whole body immune system.
  The absence of a subset of regulatory CD4+ T cells induced by bacterial a
 ntigens to express Foxp3\, also modifies the composition of gut Mb. Intere
 stingly\, the Foxp3+ T cells affect the IgA responses through their regula
 tion of GC responses\, and their depletion causes a rapid loss of specific
  IgA responses in the intestine. Together\, all these observations point t
 o the existence of a Foxp3-IgA axis in maintaining the balance of gut Mb a
 nd strongly suggest that the adaptive immune system may be a key mediator 
 of host-bacterial symbiosis.\nI will discuss our most recent findings of h
 ow the adaptive immune system is mediating host-microbial symbiosis\, by c
 ontrolling the diversification and balance of bacterial communities requir
 ed for gut homeostasis and health.
LOCATION:SV1717a http://map.epfl.ch/?room=sv1717a
STATUS:CONFIRMED
END:VEVENT
END:VCALENDAR