BEGIN:VCALENDAR VERSION:2.0 PRODID:-//Memento EPFL// BEGIN:VEVENT SUMMARY:Synthesis of Nitrogen-Containing Molecules using Inexpensive Reage nts and Catalysts: Hydroaminations\, Aminocarbonylations and Tethering Cat alysis DTSTART:20130918T171500 DTEND:20130918T183000 DTSTAMP:20260511T081135Z UID:8cd7e78ce616461bd157505af4b3b72277ff487b207202dde26afd94 CATEGORIES:Conferences - Seminars DESCRIPTION:Prof. André M. Beauchemin\, Centre for Catalysis Research and Innovation\, Department of Chemistry\, University of Ottawa\, Ottawa\, ON K1N 6N5\, Canada\nDespite the ubiquity of bioactive nitrogen-containing m olecules\, amination reactions of electron-rich alkenes and alkynes remain underdeveloped and offer excellent potential for broader applicability in the synthesis of nitrogen heterocycles\, amines and imines. Even if signi ficant efforts have been invested in the development of metal-catalyzed tr ansformations\, metal-free amination strategies utilizing bifunctional rea gents are emerging as useful alternatives. For example\, our group has sig nificantly extended the concerted\, Cope-type hydroamination reactivity of hydroxylamines and hydrazine derivatives\, enabling efficient intermolecu lar reactions and difficult cyclizations. More recently\, our lab has deve loped amino- and imino-isocyanates to achieve alkene aminocarbonylation re activity and synthesize beta-aminocarbonyl motifs under mild conditions. I n efforts to achieve elusive intermolecular hydroamination reactions of al kenes\, aldehyde-based organocatalysts were developed to in-situ form a te mporary tether between hydroxylamines and allylic amines\, thus enabling r oom temperature directed intermolecular amination reactivity and the stere ocontrolled synthesis vicinal diamines. This system highlights the potenti al of simple catalysts operating via temporary intramolecularity. Further developments of aldehyde-catalysis will also be presented. LOCATION:BCH 2218 https://plan.epfl.ch/?room==BCH%202218 STATUS:CONFIRMED END:VEVENT END:VCALENDAR