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SUMMARY:Genetic dissection of cerebral cortex development using mosaic ana
 lysis with double markers (MADM)
DTSTART:20110314T170000
DTSTAMP:20260408T034945Z
UID:a79723da54e679144bdd5ca64c0899dc10778ef263655c463b515e4f
CATEGORIES:Conferences - Seminars
DESCRIPTION:Dr Simon Hippenmeyer\, Stanford University\nThe cerebral corte
 x\, seat of our cognitive abilities\, is composed of an intricate network 
 of interconnected neurons belonging to a variety of different classes. The
  cortical cytoarchitecture consists of distinct layers with different cell
 ular composition and function. However\, it is currently not known how man
 y classes and subtypes of cortical neurons exist at all wiring up the cort
 ical circuits. The precise mechanisms how these neurons coalesce into defi
 ned laminae during development are not completely understood either. In a 
 pursuit to obtain in-depth insights into these issues I study corticogenes
 is at unprecedented single cell resolution using the genetic strategy call
 ed MADM (Mosaic Analysis with Double Markers). MADM technology offers an u
 nparalleled approach to visualize and concomitantly manipulate sparse clon
 es or subsets of genetically defined neurons in mice. My current and futur
 e research program exploits the unique features of MADM in order to addres
 s 1) the principles generating cortical cell type diversity\; 2) the cellu
 lar and molecular mechanisms controlling cortical projection neuron migrat
 ion\; 3) development of cortical afferent and efferent axonal projections\
 ; and 4) the role of genomic imprinting in cortex development. Together\, 
 these studies aim to contribute to our understanding of the fundamental ce
 llular and molecular mechanisms underlying the essential neurodevelopmenta
 l processes that control cortex assembly. In a broader context the knowled
 ge obtained from the experimental strategies outlined likely also provides
  novel critical insights into the molecular mechanisms underlying the path
 ology of the diseased brain with particular focus on neurodevelopmental di
 sorders.
LOCATION:SV2510
STATUS:CONFIRMED
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