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SUMMARY:Monitoring Mitochondrial β-Barrel Membrane Protein Folding at the
  Sorting and Assembly Machinery
DTSTART:20130926T103000
DTEND:20130926T113000
DTSTAMP:20260406T153428Z
UID:879a2439d458647f48c532d13a28aa432ec1a864f3c4b6a4c004ff90
CATEGORIES:Conferences - Seminars
DESCRIPTION:Dr. Jian QIU\nInstitute of Biochemistry and Molecular Biology\
 , University of Freiburg\, Germany\nMitochondrial β-barrel membrane prote
 ins transport biological material across the mitochondrial outer membrane.
  However\, it is unknown where the β-barrel conformation is obtained. I m
 onitored β-barrel formation by cysteine specific crosslinking and demonst
 rated that the β-barrel was formed at the sorting and assembly machinery 
 (SAM complex). Subsequently\, it was found that the central import recepto
 r Tom22 of the translocase of the outer membrane (TOM complex) interacted 
 with the SAM complex via the cytosolic receptor domain and stimulated the 
 β-barrel formation. These results support a new model of β-barrel biogen
 esis\, where Tom22 mediates the TOM-SAM interaction to promote the β-barr
 el formation at the SAM complex.
LOCATION:AI 1153 https://plan.epfl.ch/?room==AI%201153
STATUS:CONFIRMED
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