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SUMMARY:The architecture of gene regulation in development and disease 
DTSTART:20131111T140000
DTEND:20131111T150000
DTSTAMP:20260506T192920Z
UID:516fc911d91fcafa3c1d957e0af5e3f43e1403ca7e96a621c3221ea4
CATEGORIES:Conferences - Seminars
DESCRIPTION:Dr François Spitz\nDevelopmental Biology Unit\nEMBL Heidelber
 g\nGermany\nThe expression of vertebrate genes is regulated by cis-acting 
 elements that can be hundreds of kilobases away from their promoter region
 s. The importance of these remote regulatory influences is exemplified by 
 developmental malformations caused by their mutations. Results from genome
 -wide association studies suggest further that polymorphisms associated wi
 th remote regulatory elements modulate the incidence of common diseases in
  humans. Thus\, the mechanisms that control the interactions between remot
 e elements and the surrounding  genes form an essential\, yet poorly unde
 rstood\, step in the transformation of genomic information into gene expre
 ssion programs.\nTo get insights into the principles and mechanisms that o
 rganise these cis-regulatory interactions networks\, we have developed an 
 in vivo chromosomal tagging and recombineering system. The analysis of the
  distribution of regulatory activities along mouse chromosomes showed that
  enhancers act pervasively across large domains\, which overlap with the 3
 D conformation of the corresponding loci. We have engineered large series 
 of chromosomal rearrangements to alter the normal linear distribution of g
 enes\, regulatory elements and domain boundaries at several model loci\, a
 nd investigated how regulatory and physical interactions are impacted by c
 hanges in distances or relative order. As an example\, I will present how 
 our in vivo investigations of the 8q24 locus surrounding the Myc proto-onc
 ogene in the mouse identify new remote enhancers controlling tissue-specif
 ic expression of Myc (during face morphogenesis and in hematopoietic stem 
 cells)\, provide ways to move from association studies to biological funct
 ions\, and reveal the role of specific features in the organisation of the
  regulatory architecture of this complex locus.
LOCATION:SV1717A http://plan.epfl.ch/?lang=en&room=sv1717A
STATUS:CONFIRMED
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