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SUMMARY:The impact of social defeat on the cardiovascular system in rodent
 s
DTSTART:20110328T170000
DTSTAMP:20260916T043947Z
UID:276228a02f4331c4135ab6a84908f74c770327b0e4c98ba531f30932
CATEGORIES:Conferences - Seminars
DESCRIPTION:Andrea Sgoifo\nClinical and experimental data suggest that a t
 ight relationship exists among environmental stressors\, alterations of au
 tonomic neural regulation of cardiovascular homeostasis and cardiac morbid
 ity and mortality. However\, discrepancies in the results obtained emphasi
 ze the need for experimental research based on reliable animal stress mode
 ls. Among various types of environmental challenge\, social stressors are 
 the most biologically-relevant for species with complex social organizatio
 n and induce robust autonomic/endocrine activations. A number of studies p
 erformed in my lab showed that: (i) a single social defeat episode provoke
 s a transient shift of cardiac sympathovagal balance towards sympathetic p
 revalence and a remarkable incidence of arrhythmias\; (ii) tachycardic and
  arrhythmogenic effects are dampened by peripheral administration of a ser
 otonin-1A receptor agonist (8-OH-DPAT)\; (iii) threat to previously-gained
  social dominance brings about long-term alterations of heart rate circadi
 an rhythmicity\; (iv) chronic subordination induces fibrotic damage in the
  ventricular myocardium.
LOCATION:AI 1153 https://plan.epfl.ch/?room==AI%201153
STATUS:CONFIRMED
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