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SUMMARY:Genetic and Environmental Determinants of Meiotic Recombination Ra
 te Variation in Drosophila
DTSTART:20131125T091500
DTSTAMP:20260501T045117Z
UID:eff92bcd0094be451327b03cdb4bb7ad9a71dbfb44dba16e0bfe42f5
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Nadia D. Singh\, North Carolina State University\, Ralei
 gh\, NC (USA)\nBio: Nadia Singh got her start in evolutionary biology as a
 n undergraduate\, working in the lab of Steve Palumbi. She did her PhD at 
 Stanford University with Dmitri Petrov and did a postdoc at Cornell Univer
 sity with Andrew Clark and Chip Aquadro. She started her own lab at NCSU i
 n Raleigh in the Fall of 2010. Dr. Singh uses Drosophila as a model system
  to dissect the molecular evolutionary process\, such as to quantify the i
 ndividual and joint contributions of mutation\, recombination\, random gen
 etic drift\, and natural selection to patterns of evolution at the molecul
 ar scale.\nThe extensive variation in meiotic recombination rate observed 
 both within and between species remains a great paradox in evolutionary bi
 ology. Recombination is required for proper chromosome segregation during 
 meiosis and recombination defects can yield aneuploid gametes. Given the v
 ital function of meiotic recombination and the devastating consequences of
  aberrant recombination\, one might expect that recombination rates would 
 be tightly regulated. This contrasts with the dramatic variation in recomb
 ination rate observed in natural populations. Though much of the phenotypi
 c variation in recombination rate is heritable\, the genes underlying meio
 tic recombination rate variation remain unknown. The molecular mechanisms 
 underlying environmentally-induced recombination rate variation are unknow
 n as well. To address these outstanding questions\, we have taken a two-pr
 onged approach. First\, we leverage natural variation in recombination rat
 e to gain insight into the genetic architecture of this trait using an ass
 ociation mapping approach. Second\, we couple environmental perturbation w
 ith a candidate gene approach to identify environmental stimuli that induc
 e meiotic recombination rate and the genes mediating this recombinational 
 response. Our results provide the first insight into the genes and molecul
 ar mechanisms contributing to natural variation in recombination rate in D
 rosophila melanogaster and may have implications for the evolution of sex 
 and recombination.
LOCATION:SV1717A http://map.epfl.ch/?room=sv1717a
STATUS:CONFIRMED
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