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SUMMARY:“Functional and pathologic relevance of mitochondrial proteases:
  lessons from mutant mice”
DTSTART:20131216T103000
DTEND:20131216T113000
DTSTAMP:20260414T105945Z
UID:b23261d0fff381a3868df486dc3be4f20b5a1e8da8d1a3697b4d4e97
CATEGORIES:Conferences - Seminars
DESCRIPTION:Pedro Moral QUIROS\nUniversity of Oviedo\, Dept. Bioquimica y 
 Biologia Molecular\, Oviedo (Asturias)\, Spain\nMitochondria are subcellul
 ar dynamic organelles responsible to generate the bulk of energy in the ce
 ll\, regulate intermediate metabolism and control different other function
 s in the cell\, such apoptosis and calcium metabolism. During evolution\, 
 mitochondria have generated a complex quality control system\, composed by
  proteases and chaperones\, that ensure the proper function of these organ
 elles. Among all mitochondrial quality control proteases\, only a few of t
 hem have a known function\, whereas the physiological and cellular functio
 n of most of them remains unknown. We have generated mice deficient in two
  of these proteases\, Oma1 and Lonp1\, which exerts their quality control 
 function at different levels. Oma1 is a metalloprotease of the mitochondri
 al inner membrane\, which regulates mitochondrial dynamics\, whereas Lonp1
  is a serine protease of the mitochondrial matrix\, associated with the pr
 ocessing and turnover of oxidized proteins. The generation of mice deficie
 nt in both proteases has allowed us to unveil the functional relevance of 
 these proteases in different cellular processes and provide new views abou
 t their implications in different pathological conditions like metabolic d
 iseases and cancer.
LOCATION:AI 1153 https://plan.epfl.ch/?room==AI%201153
STATUS:CONFIRMED
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