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SUMMARY:Understanding the Genotype to Phenotype Transformation for Cholest
 erol Regulation
DTSTART:20131125T110000
DTEND:20131125T120000
DTSTAMP:20260507T224123Z
UID:c8df70e8eccee5bf5233673d97244891eb0568ecc4ab6e924937ed81
CATEGORIES:Conferences - Seminars
DESCRIPTION:Dr. Peter Blattmann\, Institute of Molecular Systems Biology\,
  Group of Prof. Ruedi Aebersold\, ETH\, Zurich\nBio: Dr. Blattmann studied
  biochemistry at the ETH Zurich and during his Master thesis he worked on 
 the endocytosis pathway of Human Papillomavirus in the Helenius lab. After
  his studies\, he performed an internship at Genentech in South San Franci
 sco where he worked on the interaction of viruses with dendritic cells.\nI
 n 2008\, he received a Fellowship with the European Molecular Biology Labo
 ratory (EMBL) for his PhD. His PhD thesis\, entitled “Identification and
  Characterization of Novel Cellular Cholesterol Regulators”\, was perfor
 med in the Molecular Medicine Partnership Unit (MMPU) between EMBL and the
  University Hospital Heidelberg in the groups of Dr. Rainer Pepperkok and 
 Dr. Heiko Runz. It consisted of a systematic study using RNA interference 
 and functional assays assessing cellular cholesterol uptake in order to pr
 ofile the genes reported by Genome-wide association studies (GWAS) for blo
 od lipid traits and cardiovascular disease.\nHe joined the Aebersold lab i
 n May 2013 to analyze cholesterol regulation using mass-spectrometry based
  methods.\nA seminar of the Lausanne Integrative Metabolism and Nutrition 
 Alliance (LIMNA)\nAbstract:\nCellular cholesterol regulation is a biologic
 al process underlying the complex diseases of elevated blood lipid levels 
 and cardiovascular disease in humans. Recent Genome-wide association studi
 es (GWAS) have identified many associated loci in the genome. However\, ho
 w the proteins encoded in these loci interact functionally in order to lea
 d to a complex phenotype is currently unknown. In this talk\, I will outli
 ne how we are combining state of the art targeted mass-spectrometry and mo
 deling in order to understand better the complex network of cholesterol re
 gulation.
LOCATION:AI 1 153 http://map.epfl.ch/?room=ai1153
STATUS:CONFIRMED
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