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SUMMARY:LCN Seminar: Unlearning pathological neuronal synchrony by coordin
 ated reset neuromodulation
DTSTART:20131111T100000
DTSTAMP:20260406T103732Z
UID:b83cf1e23a5f888a01adb7c8fee12769e102567c10a82765ea7d391d
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Peter TASS\, Institute of Neuroscience and Medicine\, Re
 search Centre Jülich\nSeveral brain diseases\, such as Parkinson’s dise
 ase (PD) or subjective tinnitus\, are characterized by pathological neuron
 al synchronization. With methods from non-linear dynamics and statistical 
 physics Coordinated Reset (CR) stimulation was developed to specifically c
 ounteract pathological synchrony by desynchronization. Mediated by spike t
 iming-dependent plasticity (STDP)\, neuronal activity and synaptic connect
 ivity are strongly connected. Even simple neuronal and oscillatory network
 s with STDP display a pronounced multistability\, comprising strongly sync
 hronized and synaptically connected as well as desynchronized and weakly s
 ynaptically connected states. In networks with STDP\, CR-induced desynchro
 nization causes a decrease of the rate of coincidences and\, in turn\, a d
 ecrease of the synaptic weights\, ultimately shifting networks from pathol
 ogical states to desynchronized states. As shown computationally\, the CR-
 induced unlearning of pathological synchrony can be achieved by means of d
 irect electrical stimulation or by indirect\, synaptically-mediated excita
 tory or inhibitory stimulation. Accordingly\, electrical deep brain CR sti
 mulation of the subthalamic nucleus causes pronounced long-lasting after-e
 ffects in both Parkinsonian monkeys and PD patients. By the same token\, a
 coustic CR stimulation causes a significant reduction of tinnitus symptoms
  along with a pronounced reduction of pathological neuronal synchrony\, pa
 thological effective connectivity as well as pathological cross-frequency 
 coupling within a network of tinnitus-related brain areas. A major goal of
  my theory-based approach is to further the theoretical understanding of t
 herapeutic rewiring processes and optimize and/or develop invasive as well
  as non-invasive (e.g. vibrotactile) neuromodulation techniques accordingl
 y.
LOCATION:SV1717a http://plan.epfl.ch/?room=sv1717a
STATUS:CONFIRMED
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