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SUMMARY:Molecular interplay that controls glucose and glycogen metabolism 
 in muscle 
DTSTART:20110307T113000
DTSTAMP:20260602T220703Z
UID:157c40961adda1188d38a0c46ea3daf27decd120ba2ae2e9e0927292
CATEGORIES:Conferences - Seminars
DESCRIPTION:Kr Kei Sakamoto\, MRC\, UK\nThe aim of my research is to eluci
 date the molecular mechanisms that control glucose and energy homeostasis 
 and ultimately identify novel drug targets aimed at treating metabolic dis
 orders such as type 2 diabetes. Many of the key metabolic enzymes are stri
 ctly and co-ordinately controlled through interplay between allosteric and
  covalent (e.g. phosphorylation) regulations by various extracellular and 
 intracellular factors such as hormones and energy stress. Elucidating the 
 molecular control and physiological role of such interplay is critical to 
 understand the complex metabolic processes in the body. To achieve this\, 
 we have been studying the regulatory mechanisms of key metabolic/signallin
 g enzymes and generating unique genetic models. This approach enables us t
 o establish primary mechanism by which insulin and exercise control muscle
  glucose uptake and glycogen storage in vivo.
LOCATION:AI 1153 https://plan.epfl.ch/?room==AI%201153
STATUS:CONFIRMED
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