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SUMMARY:Tools for engineering artificial cellular microenvironments
DTSTART:20131219T110000
DTEND:20131219T120000
DTSTAMP:20260407T195109Z
UID:9cd269b371c92f830a54b0323a4ed4de73fc79188e2c888035945206
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Roman Truckenmüller\nBio: Assistant Professor - MIRA In
 stitute (Institute for Biomedical Technologies and Technical Medicine)\nUn
 iversity of Twente\, The Netherlands\nRoman Truckenmüller holds an engine
 ering diploma and a doctorate in engineering science from the Universities
  of Stuttgart and Karlsruhe\, Germany\, respectively. After working as a d
 evelopment engineer for Siemens\, Erlangen\, Germany\, he worked at the In
 stitute for Microstructure Technology (IMT) of the Karlsruhe Institute of 
 Technology. At IMT\, he carried out his doctoral project on fabrication of
  three-dimensional microstructures from polymer membranes\, worked as a po
 stdoctoral researcher in the area of X-ray lithography and headed a resear
 ch group dealing with membrane-based microfluidic sensors and actuators fr
 om polymers. Since 2007\, he works at the Department of Tissue Regeneratio
 n of the University of Twente (UT)\, The Netherlands. In 2010\, he was app
 ointed assistant professor at the MIRA Institute for Biomedical Technology
  and Technical Medicine of the UT. Roman Truckenmüller’s research at MI
 RA focuses on micro- and nanoscale three-dimensional polymer film forming 
 and functionalisation technologies and their biomedical applications\, wit
 h a particular focus on engineering complex artificial cellular microenvir
 onments using the aforementioned technologies.\nThe fate of cells is close
 ly related to the nature of their physical\, chemical and biological envir
 onment. Creating artificial cellular microenvironments\, for example\, in 
 the microwells of biochips or on the surfaces of macroscopic implants allo
 ws to control the fate of seeded\, present or recruited (stem) cells conce
 rning\, among others\, their attachment\, migration\, proliferation or dif
 ferentiation. This can result in more relevant tissue\, organ or correspon
 ding disease models in vitro or in biomaterial-cell or -tissue interfaces 
 with enhanced host integration and long-term functionality in vivo. The ta
 lk will deal with tools for engineering artificial cellular microenvironme
 nts ranging from anatomically curved substrates for (for instance\, endoth
 elial) cell monolayers over tailored microwells for three-dimensional (3D)
  cell aggregates to nanowire cages for single cells. Potential application
 s of these technical 3D cell interfaces are in fields such as stem cell re
 search\, developmental biology\, cancer research\, pharmaceutical or toxic
 ological screening\, regenerative medicine or bioartificial organs (on chi
 p). Micro- and nanotechnologies allow decorating the surfaces and the bulk
  of the materials used to fabricate the artificial microenvironments on a 
 cellular\, subcellular or molecular range. Furthermore\, these technologie
 s enable the easy generation of libraries of arrayed microenvironments wit
 h\, for example\, different overall sizes and shapes\, or arrangements and
  densities of integrated micro- or nanoscale features such as correspondin
 g surface topographies or chemical domains as instructive cues. The system
 atic study or screening of the cellular responses to these designed substr
 ate-bound environmental factors can help to better understand the influenc
 ing key parameters or to find the ‘optimal’ conditions for a certain c
 ell culture or tissue engineering application.
LOCATION:BM 5202 https://plan.epfl.ch/?room==BM%205202
STATUS:CONFIRMED
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