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SUMMARY:LCN Seminar: Formation of neuronal assemblies and their maintenanc
 e during spontaneous cortical activity
DTSTART:20131219T133000
DTSTAMP:20260427T224151Z
UID:79145312db7db3e05890bf6406a14442019cdd6ed9371b121f44833e
CATEGORIES:Conferences - Seminars
DESCRIPTION:Brent DOIRON\; Theoretical Neuroscience Research Group\, Unive
 rsity of Pittsburgh\nThe patterns of fluctuating spontaneous activity cort
 ical neurons exhibit are related to the architecture in which they are emb
 edded. This architecture may be modified by sensory experience\, but the m
 echanisms that lead to the formation and persistence of structured connect
 ivity in large recurrent networks are unclear. We demonstrate a network mo
 del that can be reorganized by stimuli through realistic plasticity and ho
 meostatic mechanisms. Stimulus presentation leads to the formation of neur
 onal assemblies composed of neurons that receive common input. After train
 ing\, spontaneous activity reflects prior evoked activity and stabilizes t
 he learned network architecture. Sufficiently strong novel stimuli\, howev
 er\, can remap this architecture to reflect the new stimulus set. The mode
 l makes several predictions concerning the effect of sensory experience on
  spiking activity in spontaneous and evoked conditions. It also suggests t
 hat spontaneous activity fluctuations may consolidate learned connectivity
  patterns\, rather than simply being a source of noise.
LOCATION:SG0213 http://plan.epfl.ch/?room=sg0213
STATUS:CONFIRMED
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