BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Memento EPFL//
BEGIN:VEVENT
SUMMARY:The Ubiquitin Proteolytic System From Basic Mechanisms through Hum
 an Diseases and on to Drug Development  
DTSTART:20140116T160000
DTSTAMP:20260406T024659Z
UID:29347e4b262f75e7d9cabe76c26013c78fe7a5e573ee3c0f4c56b3ec
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Aaron Ciechanover\nBio: Nobel Prize in Chemistry 2004\nC
 ancer and Vascular Biology Research Center\, Faculty of Medicine\, Technio
 n-Israel Institute of Technology\, Haifa\, Israel\nBetween the 50s and 80s
 \, most studies in biomedicine focused on the central dogma - the translat
 ion of the information coded by DNA to RNA and proteins. Protein degradati
 on was a neglected area\, considered to be a non-specific\, dead-end proce
 ss. While it was known that proteins do turn over\, the high specificity o
 f the process - where distinct proteins are degraded only at certain time 
 points\, or when they are not needed any more\, or following denaturation/
 misfolding when their normal and active counterparts are spared - was not 
 appreciated. The discovery of the lysosome by Christian de Duve did not si
 gnificantly change this view\, as it was clear that this organelle is invo
 lved mostly in the degradation of extracellular proteins\, and their prote
 ases cannot be substrate-specific. The discovery of the complex cascade of
  the ubiquitin solved the enigma. It is clear now that degradation of cell
 ular proteins is a highly complex\, temporally controlled\, and tightly re
 gulated process that plays major roles in a variety of basic cellular proc
 esses such as cell cycle and differentiation\, communication of the cell w
 ith the extracellular environment and maintenance of the cellular quality 
 control. With the multitude of substrates targeted and the myriad processe
 s involved\, it is not surprising that aberrations in the pathway have bee
 n implicated in the pathogenesis of many diseases\, certain malignancies a
 nd neurodegeneration among them\, and that the system has become a major p
 latform for drug targeting.
LOCATION:CE 1 3 https://plan.epfl.ch/?room==CE%201%203
STATUS:CONFIRMED
END:VEVENT
END:VCALENDAR