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SUMMARY:Transition-metal-catalyzed Asymmetric Allylic Dearomatization Reac
 tions 
DTSTART:20140512T171500
DTEND:20140512T181500
DTSTAMP:20260916T120421Z
UID:399ee732c7c902e6fef0b4afa1384d94783f97a27ca280aaf597b3ca
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Shuli You\, State Key Laboratory of Organometallic Chemi
 stry\, Shanghai Institute of Organic Chemistry\, Chinese Academy of Scienc
 es\, China\nAsymmetric dearomatization reactions are particularly attracti
 ve methods in organic synthesis given the facts that the starting material
 s arenes are highly abundant and readily available\, and the dearomatizati
 on reaction would provide direct access to compounds bearing quaternary ca
 rbon center\, or polycylces and spirocycles.\nIn this talk\, the progress 
 from the You laboratory on the development of catalytic asymmetric dearoma
 tization processes will be introduced. Direct asymmetric allylic dearomati
 zation reactions of indoles\, pyrroles\, phenols\, naphthols\, and pyridin
 es were realized with a proper choice of a catalytic amount of transition-
 metal catalysts such as Ir\, Pd\, and Ru complexes. The new ligand design\
 , transformation of the dearomatized products\, mechanistic studies and sy
 nthetic application will also be discussed.\nReference:\n1. (a) Zhang\, X.
 \; Han\, L.\; You\, S.-L. Chem. Sci. 2014\, 5\, in press. (b) Zhuo\, C.-X.
 \; You\, S.-L. Angew. Chem. Int. Ed. 2013\, 52\, 10056-10059. (c) Zhuo\, C
 .-X.\; Wu\, Q.-F.\; Zhao\, Q.\; Xu\, Q.-L.\; You\, S.-L. J. Am. Chem. Soc.
  2013\, 135\, 8169-8172. (d) Liu\, W.-B.\; Zheng\, C.\; Zhuo\, C.-X.\; Dai
 \, L.-X.\; You\, S.-L. J. Am. Chem. Soc. 2012\, 134\, 4812-4821. (e) Wu\, 
 Q.-F.\; Zheng\, C.\; You\, S.-L. Angew. Chem. Int. Ed. 2012\, 51\, 1680-16
 83. (f) Zhuo\, C.-X.\; Liu\, W.-B.\; Wu\, Q.-F.\; You\, S.-L. Chem. Sci. 2
 012\, 3\, 205-208. (g) Wu\, Q.-F.\; Liu\, W.-B.\; Zhuo\, C.-X.\; Rong\, Z.
 -Q.\; Ye\, K.-Y.\; You\, S.-L. Angew. Chem. Int. Ed. 2011\, 50\, 4455-4458
 . (h) Wu\, Q.-F.\; He\, H.\; Liu\, W.-B.\; You\, S.-L. J. Am. Chem. Soc. 2
 010\, 132\, 11418-11419.
LOCATION:BCH 2218 https://plan.epfl.ch/?room==BCH%202218
STATUS:CONFIRMED
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