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SUMMARY:Molecular Mechanisms Involved in Neurodegenerative Diseases: a Gen
 etic\, Environmental and Biological Factors Study
DTSTART:20140326T140000
DTEND:20140326T150000
DTSTAMP:20260513T144057Z
UID:1e41e6a63dbf16bf5db2645bd8a7e43025f0962acc4a8697d39653d9
CATEGORIES:Conferences - Seminars
DESCRIPTION:Carl Julien\, Ph.D.\, Université de Montréal\, Québec (CA)\
 nSEMINAR of the LAUSANNE INTEGRATIVE METABOLISM and NUTRITION ALLIANCE (LI
 MNA)Abstract:\nFor many neurodegenerative diseases\, environmental and bio
 logical factors may interfere with genetic susceptibilities and lead or no
 t to disease manifestation. Here\, we found changes in fatty acid profiles
  from human brain samples of Alzheimer’s disease (AD) and Parkinson’s 
 disease (PD) patients and a decrease of SIRT1 levels in AD brain. We also 
 observed in mouse models of type 1 and type 2 diabetes and in mice anesthe
 tized an aggravation of tau and Aβ pathologies\, the two hallmarks of AD.
  We also found changes in synaptic markers and in brain fatty acid profile
 s in mice fed a high-fat diet. Moreover\, using genetic models in C. elega
 ns and mouse\, we observed involvement of endoplasmic reticulum (ER) stres
 s pathway\, the DNA-binding proteins TDP-43 and FUS\, and the secreted gro
 wth factor progranulin in polyglutamine (polyQ) toxicity found in Huntingt
 on’s disease (HD). We also investigated drugs targeting these pathways t
 o identify disease modifiers.Bio:\nDr. Julien is a Postdoctoral Fellow in 
 the Labs of Drs. Alex Parker and Pierre Drapeau\, Pathology and Cellular B
 iology\, Department of Neurosciences\, Université de Montréal\, CRCHUM\,
  Montréal\, Québec (CA)
LOCATION:AI 1153 https://plan.epfl.ch/?room==AI%201153
STATUS:CONFIRMED
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