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SUMMARY:IDOL-izing Cholesterol
DTSTART:20140401T100000
DTEND:20140401T110000
DTSTAMP:20260407T102818Z
UID:7c7116dee3ea42f95ecb60268ea69c4f205c2dc20f580b5fb28619a2
CATEGORIES:Conferences - Seminars
DESCRIPTION:Vincenzo Sorrentino\, Ph.D.\, University of Amsterdam (NL)\nSE
 MINAR of the LAUSANNE INTEGRATIVE METABOLISM and NUTRITION ALLIANCE (LIMNA
 )Abstract:\nElevated levels of plasma Low-Density-Lipoprotein cholesterol 
 (LDL-C) represent a major risk factor for development of atherosclerosis. 
 Owing to its ability to promote LDL uptake into cells the LDL receptor (LD
 LR) is an important determinant of plasma LDL level and is a target for hu
 man cardiovascular therapy. The LDLR abundance is tightly regulated both o
 n transcriptional and post-transcriptional level\, and recently the E3-ubi
 quitin ligase IDOL was identified as a novel modulator of the LDLR. Acting
  as an E3 ligase\, IDOL supports ubiquitylation of the LDLR on its protrud
 ing intracellular tail thereby targeting it for lysosomal degradation\, th
 erefore impairing the uptake of LDL in the cell. My talk will focus on the
  work I carried out on the characterization\, regulation and functional im
 plications of this novel regulatory pathway in cholesterol homeostasis.Bio
 :\n2003 – 2009\nMaster student\, Biotechnological Sciences\, Università
  degli Studi di Napoli 'Federico II' (Italy)\n2009 – 2010\nMaster studen
 t\, Swammerdam Institute for Life Sciences (SILS)\, University of Amsterda
 m (NL)\n2010 – Present\nPhD student\, Academic Medical Center (AMC)\, Un
 iversity of Amsterdam (NL)
LOCATION:AI 1153 (CHANGED) http://map.epfl.ch/?room=ai1153
STATUS:CONFIRMED
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