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SUMMARY:Monitoring of Plasma DNA for the Diagnosis of Rejection and Infect
 ion in Organ Transplantation
DTSTART:20140217T140000
DTSTAMP:20260916T203800Z
UID:7918ceafbe71cad6bc8a236a4c8e66d01c4a793e9e0bcdc866bdea8f
CATEGORIES:Conferences - Seminars
DESCRIPTION:Iwijn De Vlaminck\, PhD\, Department of Bioengineering (Quake 
 Group)\, Stanford University\, Stanford\, CA (USA)\nBio: Katholieke Univer
 siteit Leuven\, 1998 – 2003\nMaster in Science and Engineering (Burgerli
 jk Ingenieur Elektrotechniek)\, Physics\, Nanotechnology\, Electronics\nIM
 EC\, 2003-2008\nPhD\nOptics and mechanics at the nanoscale\nMetal based op
 tics or plasmonics\nNano electromechanical systems (NEMS)\nTU Delft\, 2008
  - 2011\nPostdoctoral researcher (Cees Dekker Lab)\nResearch in molecular 
 biophysics\nStanford University\, 2012- present\nPostdoctoral researcher\,
  HHMI research associate (Stephen Quake Lab)\nDNA sequencing\, single cell
  genomics and microfluidics\nDevelopment of DNA-sequencing-based methods f
 or universal and non-invasive diagnosis of both rejection and infection in
  solid-organ transplant recipients\nDNA-sequencing-based detection of vira
 l\, fungal and bacterial infections\nAbstract:\nAccurate and timely diagno
 sis of infection and allograft rejection is essential for long-term surviv
 al of solid-organ transplant recipients. We hypothesized that genomic anal
 yses of non-cellular DNA circulating in blood could simultaneously offer a
  window into the health of the transplant organ and the occurrence of vira
 l and bacterial infections. We collected plasma samples from a large group
  of lung and heart transplant recipients and purified and sequenced the ci
 rculating cell-free DNA. We found that the majority of sequences match the
  transplant recipient’s genome but sequences derived from the transplant
  donor and from a large variety of viruses\, bacteria and fungi were also 
 identified. Donor-derived DNA is likely released in the blood circulation 
 upon graft tissue damage and we found that the fraction of donor-derived D
 NA is an informative marker of transplant rejection in both lung and heart
  transplantation. We observed that the composition of viral sequences on t
 he other hand is highly dynamic and strongly affected by immunosuppressive
  and antiviral drugs. Overall\, the data provide insight into the relation
 ship between infections\, the state of the immune system\, and the effects
  of pharmacological treatment.
LOCATION:SV1717A http://map.epfl.ch/?room=sv1717a
STATUS:CONFIRMED
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