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SUMMARY:New metallic materials for biodegradable implant applications
DTSTART;VALUE=DATE:20140310
DTSTAMP:20260510T235114Z
UID:a3227dce4e7e68dab585ccc344cb550cd99780fd810f3974c9f49775
CATEGORIES:Conferences - Seminars
DESCRIPTION:Jörg Löffler\, ETHZ\, Zürich\nBiomedical implants used in o
 steosynthesis and vascular intervention are usually made of metallic mater
 ials. They are designed to have high corrosion resistance in order to rema
 in permanently in the body\, as e.g. metallic stents in vascular intervent
 ion\; or they must be removed in a second surgery\, as e.g. metallic screw
 s and plates in broken bone fixation. Permanent implants often generate pr
 oblems such as prolonged physical irritation and chronic inflammation\, an
 d can only be applied in pediatric surgery to a limited extent because the
 y do not grow with the patient. To overcome the limitations of permanent 
 devices we have developed new classes of biodegradable metallic alloys whi
 ch degrade in the body after performing their task. I will describe our e
 fforts in the development of amorphous and crystalline Mg-­‐alloys\, ba
 sed on metal physical design rules\, and present their mechanical properti
 es\, in-­‐vitro and in-­‐vivo degradation performance\, and biologic
 al response [1-­‐3]. MgZnCa alloys in particular are suitable for use a
 s biodegradable implants because they have suitable mechanical properties\
 , are biocompatible\, show good osteoconductivity and osteoinductivity\, a
 nd exhibit adjustable degradation rates.\nReferences:\n[1] B. Zberg\, P. J
 . Uggowitzer\, J. F. Löffler\, ‘MgZnCa glasses without clinically obser
 vable hydrogen evolution for\nbiodegradable implants’\, Nature Mater.  
 8 (2009) 887 – 891.\n[2] T. Kraus\, S. F. Fischerauer\, A. C. Hänzi\, P
 . J. Uggowitzer\, J. F. Löffler\, A. M. Weinberg\, ‘Magnesium alloys fo
 r\ntemporary implants in osteosynthesis: In-­‐vivo studies of their deg
 radation and interaction with bone’\, Acta\nBiomater.  8 (2012) 1230 
 – 1238.\n[3] J. Hofstetter\, M. Becker\, E. Martinelli\, A. M. Weinberg\
 , B. Mingler\, H. Kilian\, S. Pogatscher\, P. J. Uggowitzer\,\nJ. F. Löff
 ler\, ‘High-­‐strength low-­‐alloy (HSLA) Mg–Zn–Ca alloys with
  excellent biodegradation performance’\, J. of Metals (JOM) (2014)\, DOI
 : 10.1007/s11837-­‐014-­‐0875-­‐5.\nBio : Jörg F. Löffler has b
 een Professor at the Department of Materials\, ETH Zurich\, since July 200
 3. Starting as Assistant Professor\, in 2007 he was elected Full Professor
  of Metal Physics and Technology. From 2010 – 2013 he was Chairman of th
 e Department of Materials.\nBorn in Germany in 1969\, Jörg Löffler studi
 ed Physics and Materials Science at Saarland University\, Germany. Followi
 ng diploma thesis work at the Institute of New Materials in Saarbrucken wi
 th Prof. Herbert Gleiter (1994)\, he transferred to the Paul Scherrer Inst
 itute and ETH Zurich\, where he earned his doctorate in the magnetism of n
 anostructured materials and neutron scattering (1997). After a short stay 
 as a postdoctoral researcher at the Paul Scherrer Institute\, Löffler too
 k up a post at the California Institute of Technology as an Alexander von 
 Humboldt Fellow\, where he worked with Prof. William L. Johnson in the are
 a of bulk metallic glasses. In 2001 he was appointed tenure-track Assistan
 t Professor at the University of California\, Davis\, where he stayed unti
 l his appointment to ETH Zurich in 2003. Since November 2007 Jörg Löffle
 r has been Full Professor of Metal Physics and Technology.\nThe principal 
 areas of Jörg Löffler’s research are the synthesis and characterizatio
 n of novel nanostructured and amorphous materials\; magnetic\, optical\, a
 nd mechanical properties on the nanoscale\; the use of metals for medical 
 applications (in particular bioresorbable implants)\; and neutron scatteri
 ng and synchrotron radiation. His work has received distinctions at severa
 l international conferences. Other awards include the ETH Zurich Medal for
  the excellence of his Ph.D. dissertation and the Masing Memorial Award fo
 r his contributions to materials science. Jörg Löffler was a member of t
 he German National Merit Foundation from 1991 to 1997\, holds a Visiting F
 aculty position at the California Institute of Technology\, and is Adjunct
  Professor at the World Premier Institute (WPI) of Tohoku University in Se
 ndai. He is a member of the editorial boards of Intermetallics\, Metallurg
 ical and Materials Transactions A\, Journal of Nanoscience and Nanotechnol
 ogy\, and the open-access journal Results in Physics. He is also member of
  the Science Advisory Council of the European Spallation Neutron Source.
LOCATION:MXF 1 https://plan.epfl.ch/?room==MXF%201
STATUS:CONFIRMED
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