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SUMMARY:PGC1&#945\; - PGC1&#946\;: YIN-YANG IN INTESTINAL EPITHELIAL CELL 
 FATE
DTSTART:20110202T163000
DTSTAMP:20260510T022648Z
UID:fff75af8a88f2dd853d7feaf0697e1caa850f37d4748f965fdf32a44
CATEGORIES:Conferences - Seminars
DESCRIPTION:Dr Antonio Moschetta\, Lab Lipid Metabolism & Cancer\, Dept.Tr
 anslational Pharmacol\, Consorzio Mario Negri Sud\, Italy\nPGC1 alpha and 
 PGC1 beta are transcriptional coactivators able to upregulate mitochondria
 l biogenesis\, oxidative phosphorylation and fatty acid β-oxidation with 
 the final aim of providing a more efficient pathway for aerobic energy pro
 duction. In the continuously renewed intestinal epithelium\, highly glycol
 ytic proliferative cells in the crypts migrate along the villus axis and d
 ifferentiate into mature enterocytes shifting their metabolism from glycol
 ysis to oxphos and finally undergoing apoptosis. Using novel transgenic ga
 in and loss of function models we will present an intriguing scenario wher
 eby PGC1α and β are able to directly regulate intestinal epithelial cell
  fate thus modifying mucosa architecture\, enterocyte metabolic activity a
 nd cancer susceptibility.
LOCATION:AI 1153 https://plan.epfl.ch/?room==AI%201153
STATUS:CONFIRMED
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