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SUMMARY:Epigenetic Control of HPV Chromatin-Dependent Transcription
DTSTART:20110127T160000
DTSTAMP:20260503T144616Z
UID:1fb889f8b48e7cfbebba880b741cad0a291bfc71f27e910ffd1a4279
CATEGORIES:Conferences - Seminars
DESCRIPTION:Cheng-Ming Chiang\, Southwestern Medical Center\, Dallas\nTran
 scription in higher eukaryotes is controlled by an array of transcription 
 factors\, including the general transcription machinery\, general cofactor
 s\, and gene-specific activators and repressors. The complexity of gene re
 gulation is further conferred by the existence of multiple protein family 
 members recognizing consensus or non-canonical DNA-binding sequences. The 
 chromatin structure in the human genome and posttranslational modification
  on protein molecules provide an additional level of control in modulating
  gene activity. In this lecture\, I will review these control mechanisms u
 sing human papillomavirus (HPV) E6 and E2 proteins as examples to illustra
 te how DNA tumor virus-encoded transcriptional regulators are able to repr
 ogram cellular activities by targeting p53 tumor suppressor protein and ac
 tivator protein-1 (AP-1)\, respectively\, via recruitment of distinct core
 gulators\, such as p300 histone acetyltransferase and the chromatin adapto
 r bromodomain-containing protein 4 (Brd4). The interplay among these viral
  and cellular proteins and the crosstalk between different posttranslation
 al modifications regulate gene activity in response to various environment
 al stresses.
LOCATION:SV 1717 A
STATUS:CONFIRMED
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