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SUMMARY:Defining the landscape of Host-Microbiota-Diet interaction in inte
 stinal inflammation & cancer
DTSTART:20140311T140000
DTEND:20140311T150000
DTSTAMP:20260428T060046Z
UID:cff44d14c454731a37116c88848148d1d2cfafaa6aff8ede271205d3
CATEGORIES:Conferences - Seminars
DESCRIPTION:Yiorgos Apidianakis\nThe gastrointestinal tract is habitable b
 y a variety of microorganisms and it is often a tissue inflicted by inflam
 mation. Much discussion is raised in recent years about the role of microb
 iota in intestinal inflammation and its role in intestinal cancer. I will 
 discuss our work on Drosophila melanogaster models of tumorigenesis and tu
 mor cell invasion upon intestinal infection. In Drosophila midgut\, bacter
 ia that cause enterocyte damage induce intestinal stem cell proliferation\
 , which is diverted towards aberrant stem cell expansion upon oncogene exp
 ression to induce dysplastic tumors. In Drosophila hindgut\, oncogenes syn
 ergize with the innate immune response to induce tumor cell invasion and d
 issemination to distant sites. Based on these Drosophila models a multi-pa
 rameter and combinatorial analysis of host genetic factors\, human intesti
 nal microbiota and diet can be performed to systematically assess pivotal 
 aspects of intestinal inflammation and cancer.
LOCATION:AI 1153 https://plan.epfl.ch/?room==AI%201153
STATUS:CONFIRMED
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