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SUMMARY:‘Particle Genetics’: Treating Every Cell as Unique
DTSTART:20140325T110000
DTSTAMP:20260508T083514Z
UID:f95f6609f0bcd517851b7eb2e279bc3c15d6b946f7681f06fe285417
CATEGORIES:Conferences - Seminars
DESCRIPTION:Gaël Yvert\, Ph.D.\, École Normale Supérieure\, Lyon (F)\nB
 IOENGINEERING SEMINARAbstract:\nWe are exploring a novel angle of genetics
  by studying how genotypes shape the statistical properties of single-cell
  phenotypic traits.  Using yeast as an experimental model system\, we fou
 nd that natural genetic backgrounds confer different statistical propertie
 s of single-cell molecular and cellular traits. For example\, some wild ye
 ast strains display elevated cell-cell trait variability as compared to ot
 her strains. Genomic loci causing probabilistic changes can be identified\
 , illustrating that QTL scans can be extended to a probabilistic framework
  where cellular individualities are considered. In multicellular organisms
 \, this non-deterministic approach may be particularly appropriate to stud
 y macroscopic phenotypes that emerge from rare cells\, such as cancer. I w
 ill also present a technology able to track the metabolic activity of sing
 le yeast cells in real time\, which offers exciting perspectives to screen
  for microorganisms of industrial potential.Bio:\n1992-1995:  École Poly
 technique (Palaiseau\, Paris\, France)\n1995-1996:  Diplôme d'Étude App
 rofondie (DEA) in Molecular and Cellular Biology from Pasteur University\,
  Strasbourg (F)\nResearch topic: Cloning of the gene responsible for spino
 cerebellar ataxia type 2\nMentor: Jean-Louis Mandel\, Institut Génétique
  de Biologie Moléculaire Cellulaire (IGBMC)\, Illkirch\n1996-2000: Ph.D. 
 in Molecular and Cellular Biology\nTitle: Neurodegenerative diseases due t
 o polyglutamine expansions: identification of two causative genes and deve
 lopment of animal models.\nMentor: Jean-Louis Mandel\, IGBMC.\n2001-2002: 
 Postdoc at the Fred Hutchinson Cancer Research Center\, Howard Hughes Medi
 cal Institute\, Seattle\, WA (USA)\nFellowship from the Human Frontier Sci
 ence Program\nResearch topic: Genetics of genome expression regulation in 
 yeast\nMentor: Leonid Kruglyak\n2003:  Hired at Centre National de la Rec
 herche Scientifique (CNRS)\; joined group of Jean-Marie François in Toulo
 use (F)\n2005: Launches group "Genetics of Intra-Species Variations" at É
 cole Normale Supérieure de Lyon\nSupported by Young Investigator grant (A
 TIP) from CNRS\n2007: "HDR" Degree\, French post-Ph.D. diploma allowing to
  supervise research programs\n2007-2010: consultant for Lesaffre Internati
 onal\n2011: Promoted to CNRS Director of Research (DR2)Speaker's Lab homep
 age
LOCATION:SV1717A http://map.epfl.ch/?room=sv1717a
STATUS:CONFIRMED
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