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SUMMARY:Interactome Networks and Human Disease
DTSTART:20140402T121500
DTSTAMP:20260509T055129Z
UID:4381aecf5fc232eef0ffbcfa3d9b9cea15fa3b0f6328d8b357f45e0e
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Marc Vidal\nCenter for Cancer Systems Biology (CCSB) and
  Department of\nCancer Biology Dana-Farber Cancer Institute\nFor over half
  a century it has been conjectured that macromolecules form complex networ
 ks of functionally interacting components\, and that the molecular mechani
 sms underlying most biological processes correspond to particular steady s
 tates adopted by such cellular networks. However\, until a decade ago\, sy
 stems-level theoretical conjectures remained largely unappreciated\, mainl
 y because of lack of supporting experimental data.\nTo generate the inform
 ation necessary to eventually address how complex cellular networks relate
  to biology\, we initiated\, at the scale of the whole proteome\, an integ
 rated approach for modeling protein-protein interaction or “interactome
 ” networks. Our main questions are: How are interactome networks organiz
 ed at the scale of the whole cell? How can we uncover local and global fea
 tures underlying this organization\, and how are interactome networks modi
 fied in human disease\, such as cancer?\nBio: Dr. Vidal received his PhD i
 n 1991 from Gembloux University (Belgium) for work performed at Northweste
 rn University. He identified the yeast genes SIN3 and RPD3\, and demonstra
 ted that they encode global transcriptional regulators. During postdoctora
 l training at the Massachusetts General Hospital Cancer Center\, he develo
 ped the reverse two-hybrid system to genetically characterize protein-prot
 ein interactions. In 2000\, he joined DFCI\, where his research focuses on
  understanding global and local properties of interactome networks.
LOCATION:SV 1717a http://map.epfl.ch/?room=sv1717a
STATUS:CONFIRMED
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