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SUMMARY:Functional MRI in Mice: Towards the Analysis of Networks
DTSTART:20140401T161500
DTSTAMP:20260506T061751Z
UID:11cddb57edf48ba5d5d07e682878fad18bb5e9f2d86232eba1f56123
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Markus Rudin\,  University of Zurich and ETH Zurich (CH
 )\nBIOENGINEERING SEMINARAbstract:\nFunctional magnetic resonance imaging 
 (fMRI) in rodents is attractive in many regards: 1. By combining fMRI with
  established invasive readouts of neuronal function mechanistic informatio
 n on the link of the hemodynamic response to the underlying neural activit
 y can be obtained. 2. Genetically engineered mouse lines allow identifying
  the specific molecular mediators involved in signal processing. 3. The re
 latively simple morphology of the cortical vasculature enables detailed an
 alyses of the functional topology and its rearrangements following focal C
 NS injury. 4. Modern fMRI techniques allow for full three-dimensional cove
 rage of the brain essential for the elucidation of large scale networks in
 volved in specific tasks\, during pharmacological activation or at rest.\n
 Challenges in mouse fMRI are linked to the small dimensions and the high d
 emands on spatial resolution\, to animal physiology\, which should be stab
 le enough to allow for detection of percent changes in signal intensity\, 
 and to potential interference by anaesthesia. Yet\, technical solutions ar
 e available and mouse fMRI is becoming established. The different aspects 
 of rodent fMRI will be illustrated. Mechanistic information on neurovascul
 ar coupling was obtained by combined fMRI/fiber-optics measurement of the 
 bulk Ca2+ signal in the rat using a fluorescent ligand\; a potential role 
 of glia in determining the vascular signal has been implicated. A critical
  aspect in rodent fMRI is the impact of anesthesia. We have therefore comp
 ared four anesthetics with regard to their effects on stimulus evoked fMRI
  responses and functional connectivity patterns. Anesthetics affect signal
 s in a differential manner that can be rationalized in terms of anesthesia
  depth\, mechanism of action and effects on the cerebral vasculature. Rest
 ing-state fMRI has been applied to analyse alteration in network patterns 
 in a murine model of cerebral amyloidosis. Finally fMRI following the admi
 nistration of serotonin agonists in mice have revealed activation in brain
  structures associated with serotonergic signaling\, which was found alter
 ed in a mouse model of acquired depressive behavior. Interestingly\, chang
 es in serotonergic networks were transmitted to the offsprings of affected
  generation.Bio:\nMarkus Rudin is full professor for Molecular Imaging and
  Functional Pharmacology at the Institute for Biomedical Engineering (D-IT
 ET) since June 2006. Since March 2005 he is also full professor for Molecu
 lar Imaging and Functional Pharmacology at the University of Zürich both 
 at the Institute for Biomedical Engineering and the Institute for Pharmaco
 logy and Toxicology.\nMarkus Rudin (born 1953\, from Lauwil BL) received h
 is diploma in chemistry at the ETHZ in 1976 and his PhD at the Laboratory 
 for Physical Chemistry in 1981 in the field of electron spin resonance / e
 lectron-nuclear double resonance\, followed by a post-doctorate in the sam
 e area. In 1983 he moved to biomedical imaging\, joining Sandoz AG to buil
 d up a biomedical imaging group initially focused on magnetic resonance im
 aging. He received his basic training in imaging at the Biocenter of the U
 niversity of Basel. Within Sandoz AG\, later Novartis Pharma AG\, he becam
 e head of the Biophysics Group\, head of the In-vivo Models Unit and final
 ly head of the Analytical and Imaging Science Unit within Discovery Techno
 logies at the Novartis Institutes for Biomedical Research. In this functio
 n he was also deputy head of Discovery Technologies until 2005. In 1997 he
  became Privat Dozent for Biophysics at the University of Basel. Since Mar
 ch 2005\, he is member of the Research Council of the Swiss National Scien
 ce Foundation.\nMarkus Rudin is heading a research group at the animal ima
 ging center of UZH and ETH located at ETH Hönggerberg focusing on MRI and
  optical imaging methods (fluorescence tomography). His research focus is 
 the development of non-invasive imaging techniques for studying structure\
 , physiology\, and metabolism of tissue as well as cellular and molecular 
 events in the intact organism\, in particular assays for monitoring signal
  transduction pathways. Biomedical applications are in neuroscience and me
 tabolic diseases.Speaker's personal web page
LOCATION:SV1717A http://map.epfl.ch/?room=sv1717a
STATUS:CONFIRMED
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