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SUMMARY:The non-canonical Hedgehog/AMPK pathway regulates polyamine metabo
 lism to support neuronal and medulloblastoma cell growth
DTSTART:20140429T103000
DTEND:20140429T113000
DTSTAMP:20260920T110349Z
UID:d6123fbd677fe62e19f90058eb4ddbff99054ebad56e3bf4fe4b6641
CATEGORIES:Conferences - Seminars
DESCRIPTION:Davide D’Amico\, PhD\, University of Rome La Sapienza (I)\nS
 EMINAR of the LAUSANNE INTEGRATIVE METABOLISM and NUTRITION ALLIANCE (LIMN
 A)Abstract:\nInappropriate activation of the Hedgehog signaling is a leadi
 ng cause of medulloblastoma and pharmacological targeting of Hedgehog down
 stream components represents a promising therapeutic strategy. This semina
 r will discuss how Hedgehog promotes polyamine biosynthesis by engaging a 
 non-canonical axis leading to ODC translation. This process is governed by
  AMPK\, which phosphorylates CNBP in response to Hedgehog activation. Nota
 bly\, elevated CNBP\, ODC and polyamines are hallmarks of Hedgehog-depende
 nt medulloblastoma and inhibition of ODC with DFMO efficiently blocks Hedg
 ehog-dependent proliferation of medulloblastoma cells. Together\, these da
 ta illustrate an unexpected auxiliary mechanism of metabolic control by a 
 morphogenic pathway with relevant implications in cancer therapy.Bio:\nD. 
 D’Amico\, currently at the Department of Molecular Medicine\, University
  of Rome "La Sapienza"\, Rome (I)\, holds a Ph.D. degree from La Sapienza 
 obtained under the supervision of Prof. Gianluca Canettieri (Research Unit
  on Epigenetics\, Metabolism and Cancer).
LOCATION:AI 1153 https://plan.epfl.ch/?room==AI%201153
STATUS:CONFIRMED
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