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SUMMARY:Impact of the gut microbiota on intestinal tissue remodeling
DTSTART:20140414T133000
DTSTAMP:20260916T043955Z
UID:a4695a5544b20f006fc4e2899e9725698356944ef99a74d5db1be258
CATEGORIES:Conferences - Seminars
DESCRIPTION:Christoph Reinhardt\nUniversity Medical Center\, Johannes Gute
 nberg-University Mainz\, Germany\nThe human intestine is the organ with th
 e most rapid renewal rates in the body. The underlying pathways involved i
 n gut development need to be tightly controlled. It harbors a densely colo
 nized ecosystem\, the gut microbiota. Gut microbial communities profoundly
  impact on mucosal morphology and cellular renewal. If the balance of sign
 aling mechanisms that control intestinal renewal is disturbed either by dy
 sbiosis\, infection or by mutation of growth regulatory genes this can res
 ult in impaired intestinal barrier function\, polyp formation or even infl
 ammatory bowel disease (IBD) and the deve lopment of intestinal cancers. I
 ntestinal inflammation (e.g. necrotizing enterocolitis\, IBD\, chemotherap
 y - induced mucositis) severely affects intestinal renewal and Crohn.s pat
 ients are at increased risk of developing intestinal cancers. Now that we 
 began to understand how the intestinal architecture and cell renewal is co
 ntrolled\, it is a timely and plausible consequence to use germfree (GF) m
 ouse technology to study how colonization with a gut microbiota or single 
 microbes impacts on the steady state of m orphogenic signaling. To date\, 
 the pathways that are triggered by the gut microbiota and can modulate cel
 lular renewal in the intestine are elusive. With GF mouse models we reveal
 ed that the gut microbiota triggers coagulation factor signaling thus elic
 iti ng remodeling of intricate capillary networks in the intestinal mucosa
 . Our research aims to explore how gut microbial communities can modulate 
 the morphology of their habitat and we will pinpoint growth regulatory com
 ponents that are affected by dysbiosis and acute intestinal inflammation. 
 Detailed understanding of microbiota dependent morphogenic signaling will 
 foster the development of new probiotics to ameliorate intestinal inflamma
 tory disease states.\nGlobal Health Institute RECRUITING SEMINAR
LOCATION:SV 1717a http://map.epfl.ch/?room=sv1717a
STATUS:CONFIRMED
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